Application of Charged Aerosol HPLC Detection in biopharmaceutical Analysis

O-linked glycans are released from proteins by reductive β-elimination. The released glycans are separated by ultra high performance liquid chromatography (UHPLC) on a new UHPLC platform that integrates the charged aerosol detector into the system for increased performance and ease…

In M M G N-linked glycans are released from proteins by PNGase-F. The released glycans are separated by ultra high performance liquid chromatography (UHPLC) on a new UHPLC platform that integrates the charged aerosol detector into the system for increased…

Dave Thomas and Ian Acworth Thermo Fisher Scientific, Chelmsford, MA Ap plica t ion Note 1 1 27 Label-Free Analysis by UHPLC with Charged Aerosol Detection of Glycans Separated by Charge, Size, and Isomeric Structure Key Words Glycan Quantitation, Glycan…

Discover what you’re missing Thermo Scientific Charged Aerosol Detectors Hidden peaks revealed The analyte detection challenge No single liquid chromatography (LC) detector delivers ideal results. Often, one analyte responds more strongly than another, or may not respond at all. What…