NEW FEATURES IN BIOINFORMATICS SOFTWARE FOR AUTOMATED PROCESSING OF HDX MS DATA

LOCALIZED CONFORMATION ANALYSES OF MUTATED HUMAN IgG1 BY HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY AND DIFFERENTIAL SCANNING CALORIMETRY Joomi Ahn 1, Xiaojun Lu2, Colette Quinn3, St John Skilton1, Ying Qing Yu1, and Jihong Wang2 1 Waters Corporation, 2 MedImmune, 3TA Instruments…

DynamX HDX Data Analysis Software 3.0 Simplifying Hydrogen Deuterium Exchange Interpretation P ROT EIN CONFORMAT ION ANALYSIS MADE SIM P LE In HDX MS studies, replicate data are collected across multiple time points and varied species (native vs. mutant, innovator…

INNOVATOR AND BIOSIMILAR INFLIXIMAB: COMPARABILITY ASSESSMENT OF THE HOST CELL PROTEINS AND PROTEIN HIGHER ORDER STRUCTURE Catalin Doneanu1, Jing Fang1, Alain Beck2, Weibin Chen1 and Ying Qing Yu1 1 Waters Corporation, Milford MA, 2Institute de Recherche Pierre Fabre, Centre d'Immunologie,…

ACQUITY UPLC M-Class System with HDX Technology Integration of Hydrogen Deuterium Exchange with High Resolution MS QUANT IF Y CHANGES IN P ROT EIN CONFORMAT ION W IT H CONFIDENC E The Waters ® ACQUITY UPLC ® M-Class System with…