LOCALIZED CONFORMATION ANALYSES OF MUTATED HUMAN IgG1 BY HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY AND DIFFERENTIAL SCANNING CALORIMETRY

Conformational Characterization of Calmodulin by Hydrogen Deuterium Exchange Mass Spectrometry Joomi Ahn, Martha Stapels, Michael Eggertson, Keith Fadgen, and Ying Qing Yu Waters Corporation, Milford, MA, U.S. A P P L I C AT I O N B E N…

DynamX HDX Data Analysis Software 3.0 Simplifying Hydrogen Deuterium Exchange Interpretation P ROT EIN CONFORMAT ION ANALYSIS MADE SIM P LE In HDX MS studies, replicate data are collected across multiple time points and varied species (native vs. mutant, innovator…

1 PhD Dile Holton, Colette Quin, PhD.1 Characterizing Weak Binding Events with Two Advanced Biophysical Techniques: Hydrogen Deuterium Exchange (HDX-MS) and Differential Scanning Calorimetry (DSC) 1 2 Ahn Joomi 2 Asish Chakraborty 2 Ying Qing Yu, PhD – TA Instruments,…

NEW FEATURES IN BIOINFORMATICS SOFTWARE FOR AUTOMATED PROCESSING OF HDX MS DATA Jing Fang, Ying Qing Yu, Keith Fadgen, Michael Eggerton, Rose Lawler, Asish Chakraborty Waters Corporation, Milford, MA USA INTRODUCTION RESULTS AND DISCUSSION Intact Protein Analysis DynamX is an…