HPLC Enantiomeric Separations of Pharmaceuticals Using Polar Organic Mobile Phases

Basics of Chiral HPLC Definitions Principles Available CSPs Mobile phase types T408109 sigma-aldrich.com The Field of Stereochemistry 1. All isomers have same chemical formula but differ in the arrangement of certain chemical groups in space. 2. Many types of isomers…

Sigma-Aldrich Integrated Chiral Services • Paul Rodwell and Thierry Bonnaud Chirality 2012 Fort Worth, Texas, 10th-13th June Agenda • • • • • • • • Introduction Sigma-Aldrich Integrated Chiral Services Capability SAFC Pharmorphix® Chiral Services Overview Chiral Method Development…

A Novel Approach in HPLC Chiral Method Development: Dealing with Multiple Chiral Centers David S. Bell1, Anders Fridstrom2, and Gaurang Parmar1 1Supelco, Div. of Sigma-Aldrich Bellefonte, PA 16823 USA 2Sigma-Aldrich GmbH Industriestrasse 25 CH-9471 Buchs, Switzerland sigma-aldrich.com/analytical T413140 © 2013…

Utilizing Enantiomeric Separations in Bioanalysis Craig R. Aurand, Hillel K. Brandes, David S. Bell, Wayne Way, and Carmen T. Santasania Supelco, Div. of Sigma-Aldrich, Bellefonte, PA 16823 USA www.sigma-aldrich.com T410094 Abstract Enantiomeric separations are often restricted in bioanalysis due to…