Basics of Chiral HPLC

HPLC Enantiomeric Separations of Pharmaceuticals Using Polar Organic Mobile Phases •J.T. Lee and William Campbell Supelco, Div. of Sigma-Aldrich, Bellefonte, PA 16823 USA sigma-aldrich.com T411054 Agenda • • • • • • • • • Background Benefits Mechanisms Separation Comparisons…

Perform Fast, High-efficiency Chiral Separations Like Never Before InfinityLab Poroshell 120 Chiral Columns Cover Every Single Step of Your Chiral Workflow Chiral enantiomers differ in their biochemical properties, and it is well recognized that racemic and enantiomeric products must be…

A Novel Approach in HPLC Chiral Method Development: Dealing with Multiple Chiral Centers David S. Bell1, Anders Fridstrom2, and Gaurang Parmar1 1Supelco, Div. of Sigma-Aldrich Bellefonte, PA 16823 USA 2Sigma-Aldrich GmbH Industriestrasse 25 CH-9471 Buchs, Switzerland sigma-aldrich.com/analytical T413140 © 2013…

Utilizing Enantiomeric Separations in Bioanalysis Craig R. Aurand, Hillel K. Brandes, David S. Bell, Wayne Way, and Carmen T. Santasania Supelco, Div. of Sigma-Aldrich, Bellefonte, PA 16823 USA www.sigma-aldrich.com T410094 Abstract Enantiomeric separations are often restricted in bioanalysis due to…