OVERCOMING PEAK CAPACITY LIMITATIONS IMPOSED BY HYDROGEN EXCHANGE QUENCH CONDITIONS

SUICIDE INHIBITION OF ONCOGENIC K-RAS G12C PROCEEDS VIA SHIFT TO THE INACTIVE CONFORMATION Rane A. Harrison1, Sang Min Lim2,3, John C. Hunter4, Kenneth D. Westover4, Nathanael S. Gray2,3, John R. Engen1 1Department of Chemistry & Chemical Biology, Northeastern University, Boston,…

Conformational Characterization of Calmodulin by Hydrogen Deuterium Exchange Mass Spectrometry Joomi Ahn, Martha Stapels, Michael Eggertson, Keith Fadgen, and Ying Qing Yu Waters Corporation, Milford, MA, U.S. A P P L I C AT I O N B E N…

ACQUITY UPLC M-Class System with HDX Technology Integration of Hydrogen Deuterium Exchange with High Resolution MS QUANT IF Y CHANGES IN P ROT EIN CONFORMAT ION W IT H CONFIDENC E The Waters ® ACQUITY UPLC ® M-Class System with…

HIGHER SENSITIVITY, DATA QUALITY AND THROUGHPUT FOR HYDROGEN DEUTERIUM EXCHANGE EXPERIMENTS WITH EXTENDED ION MOBILITY SEPARATION Alexandre F. Gomes[1], Lindsay Morrison[1], Malcolm Anderson[2], Colette Quinn[1] [1] Waters Corporation, 34 Maple St., Milford, MA, 01757, USA [2] Waters Corporation, Stamford Avenue,…