SUICIDE INHIBITION OF ONCOGENIC K-RAS G12C PROCEEDS VIA SHIFT TO THE INACTIVE CONFORMATION

Conformational Characterization of Calmodulin by Hydrogen Deuterium Exchange Mass Spectrometry Joomi Ahn, Martha Stapels, Michael Eggertson, Keith Fadgen, and Ying Qing Yu Waters Corporation, Milford, MA, U.S. A P P L I C AT I O N B E N…

WHITE PAPER 65872 Hydrogen deuterium exchange mass spectrometry for the masses Executive summary Determining the shape and dynamics of proteins and protein complexes is crucial to understanding protein function and the roles proteins play in biological systems. Traditional techniques employed…

ACQUITY UPLC M-Class System with HDX Technology Integration of Hydrogen Deuterium Exchange with High Resolution MS QUANT IF Y CHANGES IN P ROT EIN CONFORMAT ION W IT H CONFIDENC E The Waters ® ACQUITY UPLC ® M-Class System with…

TECHNICAL NOTE 65887 Hydrogen deuterium exchange mass spectrometry for protein structural characterization Authors: Terry Zhang and Rosa Viner Thermo Fisher Scientific, San Jose, CA, USA Keywords: Peptide mapping, protein conformation, bottom-up, deuterium uptake, hydrogen deuterium exchange mass spectrometry, HDX-MS, HDX,…