Pressurized Online Pepsin Digestion of mAb IgG2 for Hydrogen Deuterium Exchange Mass Spectrometry

PRESSURIZED ONLINE PEPSIN DIGESTION OF PROTEINS FOR HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY Jing Fang, Ying Qing Yu, Rose Lawler, Keith Fadgen, Michael Eggertson, and Asish Chakraborty Waters Corp., Milford, MA, US RESULTS AND DISCUSSION INTRODUCTION Online pepsin digestion has been widely…

[ TECHNOLOGY BRIEF ] Enhanced Performance of the SYNAPT XS and Its Impact on Hydrogen Deuterium Exchange Mass Spectrometry (HDX MS) Data Quality Lindsay Morrison, Malcolm Anderson, and Colette Quinn Waters Corporation, Milford, MA, USA The SYNAPT XS provides enhanced…

ACQUITY UPLC M-Class System with HDX Technology Integration of Hydrogen Deuterium Exchange with High Resolution MS QUANT IF Y CHANGES IN P ROT EIN CONFORMAT ION W IT H CONFIDENC E The Waters ® ACQUITY UPLC ® M-Class System with…

TECHNICAL NOTE 65887 Hydrogen deuterium exchange mass spectrometry for protein structural characterization Authors: Terry Zhang and Rosa Viner Thermo Fisher Scientific, San Jose, CA, USA Keywords: Peptide mapping, protein conformation, bottom-up, deuterium uptake, hydrogen deuterium exchange mass spectrometry, HDX-MS, HDX,…