HIGHER SENSITIVITY, DATA QUALITY AND THROUGHPUT FOR HYDROGEN DEUTERIUM EXCHANGE EXPERIMENTS WITH EXTENDED ION MOBILITY SEPARATION Alexandre F. Gomes[1], Lindsay Morrison[1], Malcolm Anderson[2], Colette Quinn[1] [1] Waters Corporation, 34 Maple St., Milford, MA, 01757, USA [2] Waters Corporation, Stamford Avenue,…
Application Note Hydrogen Deuterium Exchange Coupled with SELECT SERIES Cyclic IMS Mass Spectrometer for Higher Workflow Efficiency Lindsay Morrison, Malcolm Anderson, Alexandre Gomes Waters Corporation For research use only. Not for use in diagnostic procedures. Abstract Hydrogen deuterium exchange is…
[ APPLICATION NOTE ] Pressurized Online Pepsin Digestion of mAb IgG2 for Hydrogen Deuterium Exchange Mass Spectrometry Jing Fang, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION An enhanced-pressure (up to ~ 15,000 psi),…
PRESSURIZED ONLINE PEPSIN DIGESTION OF PROTEINS FOR HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY Jing Fang, Ying Qing Yu, Rose Lawler, Keith Fadgen, Michael Eggertson, and Asish Chakraborty Waters Corp., Milford, MA, US RESULTS AND DISCUSSION INTRODUCTION Online pepsin digestion has been widely…
