Advancing Anti-Doping Science: Analytical Strategies for the Evolving Fight Against Doping
Modern anti-doping laboratories use LC-MS, GC-MS/MS, HRMS and IRMS for broad screening, confident confirmation and detection of emerging prohibited substances.
Integrated Multi-Omics Profiling of Thymoma Identifies Subtype-Specific Remodeling and Myasthenia Gravis-Associated Targets
Multi-omics profiling of thymoma identifies subtype-specific metabolic, lipid, and protein changes and reveals molecular targets associated with myasthenia gravis.
This week we bring you technical note by KNAUER, application note by Shimadzu and posters by Thermo Fisher Scientific / HPLC Symposium and Waters Corporation / AOAC!
LCMSGCMSICPMSScientific article | Science and research
Propionic Acid Outperforms Formic and Acetic Acid in MS Sensitivity for High-Flow Reversed-Phase LC-MS Bottom-Up Proteomics
Propionic acid increases peptide identifications by 39% versus formic acid in LC-MS proteomics while maintaining chromatographic performance and compatibility.
One Injection, Two Answers: Introducing Squad Metabolomics on Orbitrap Mass Spectrometers
SQUAD metabolomics combines targeted quantitation and untargeted discovery in a single Orbitrap MS experiment, delivering confident quantitative results alongside broad metabolite profiling.
Electrospray 101: What to Know About LC-MS Sources – and a First Look at Optispray
Discover how ion sources shape LC-MS performance and why electrospray transformed modern mass spectrometry. Explore EASY-Spray™, NanoSpray Flex™, and the new OptiSpray™ technology.
Exploring a Versatile LC–HRMS Strategy for NDSRI Determination in Beta Blocker Drug Substances
A single LC-HRMS method for NDSRI quantitation across six beta blockers. Discover how Orbitrap MS enables sensitive, robust analysis of trace nitrosamine impurities.
LCMSICPMSScientific article | Science and research
Benchmarking Lysosome Enrichment Methods: A Guide for Research and Clinical Translation
This study benchmarks four lysosome isolation techniques, highlighting trade-offs in enrichment, purity, scalability, and reproducibility.
Monitoring mAb Manufacturing the Easy Way with Switchable 2D‑LC-UV-MS
How can mAb manufacturing monitoring be simplified? Switchable 2D-LC-UV-MS workflows enable near real-time tracking of critical quality attributes and faster process decisions.
Sharper, Faster, Smarter: HRAM Orbitrap Mass Spectrometry Meets Postmortem Toxicology
HRAM Orbitrap LC-MS accelerates postmortem toxicology, enables retrospective screening for emerging drugs, and improves confidence in complex sample analysis.