<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 18th May 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application note by<strong> Shimadzu, </strong>poster by <strong>MDCW / InfoMass</strong> and brochure by <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. MDCW / InfoMass: Development of a Fully Software-Controlled, Alignment-Free Loop-Delay Thermal Modulator for GC×GC</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_22_Wu_0662310ba1.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>Loop-delay thermal modulation is a well-established approach for comprehensive two-dimensional gas chromatography (GC×GC) and inherently requires precise alignment of the modulation loop. In conventional designs, this alignment must be performed manually by the user, a process that is difficult, time-consuming, and often unreliable, as the modulation loop can shift during operation due to repeated hot-jet gas pulses, leading to misalignment and degraded modulation performance. This work addresses these limitations through a redesigned loop-delay modulator in which precise alignment is ensured intrinsically by the modulator geometry, eliminating user-dependent alignment while improving mechanical stability and operational robustness.&nbsp;</p><h4><strong>Key Improvements &nbsp;</strong></h4><ul><li>Intrinsic loop alignment by geometry, eliminating user-performed alignment&nbsp;</li><li>Mechanically secured loop holder, preventing loop movement during hot-jet gas pulses &nbsp;</li><li>Easy loop winding, simplifying installation and replacement&nbsp;</li><li>No moving mechanical parts, improving robustness and reliability&nbsp;</li><li>Fully software-controlled modulation, including hot-jet temperature, valve timing, modulation period, and cold-jet gas flow&nbsp;</li><li>Programmable cold-jet gas flow, providing indirect control of modulation temperature&nbsp;</li><li>Programmable modulation period, enabling flexible optimization for correcting peak wrap-around.&nbsp;</li><li>Independent of GC controls, enabling standalone operation</li></ul><h4><strong>Installation and Compatibility&nbsp;</strong></h4><p>Precise loop alignment is automatically achieved through the modulator’s mechanical design. The loop remains fixed during operation and is not affected by hot-jet gas pulses. The compact, modular system is compatible with most commercial gas chromatographs and operates independently of GC control hardware and software</p><h3><strong>2. Shimadzu: Simultaneous Analysis of Methoxypyrazines in Processed Tomato Products by GC–MS/MS with SPME Arrow</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01141_en_78979e911f.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>SPME Arrow enables high-sensitivity determination of methoxypyrazines in processed tomato products by efficiently preconcentrating volatile compounds.</li><li>GC–MS/MS in MRM mode provides isomer selectivity and reliable quantitation of methoxypyrazines, even in complex sample matrices.</li><li>The AOC-6000 Plus multifunctional autosampler automates SPME Arrow injection to increase throughput and improve repeatability.</li></ul><p>In processed vegetable foods and beverages, small changes in aroma and flavor can strongly affect perceived quality. For processed tomato products in particular, a vegetative (green) or hay-like off-flavor is often a key concern. This off-flavor has been linked to methoxypyrazines present at very low levels (ppt levels around 10 ng/L).&nbsp;</p><p>Methoxypyrazines include many closely related analogs. Therefore, a robust quantitative method must deliver both high sensitivity and sufficient selectivity (and/or separation) to handle real matrices.&nbsp;</p><p>In this article, five methoxypyrazines previously detected in vegetables (Table 1) were analyzed using a GC-MS/MS system with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=SPME+Arrow"><strong>SPME Arrow</strong></a> injection method. The method provides stable quantitation at ng/L (ppt) levels, even in complex, interference-rich samples.</p><h4><strong>System Configuration</strong></h4><p>All measurements were performed with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-TQ8040+NX"><strong>GCMS-TQ8040 NX triple quadrupole</strong></a> GC–MS/MS system equipped with an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=AOC6000+Plus"><strong>AOC6000 Plus</strong></a> multifunctional autosampler (Fig. 1).&nbsp;</p><p>The AOC-6000 Plus supports multiple sample introduction techniques—including liquid injection, headspace, and SPME— and can switch between them automatically based on the method. This flexibility makes it well suited for laboratories that handle many sample types and applications.</p><h4><strong>Conclusion</strong></h4><p>By using an AOC-6000 Plus autosampler with the GCMS-TQ8040 NX system and optimizing the SPME Arrow injection method, five off-flavor methoxypyrazines were successfully measured at ng/L (ppt) levels. Using MRM improved selectivity and enabled isomer-specific analysis, including differentiation of isomers that are difficultto separate by GC alone.&nbsp;</p><p>When applied to real processed tomato products, the method enabled quantitation of 2-methoxy-3,5-dimethylpyrazine (MDMP). This system reduces matrix interference and provides high sensitivity for trace-level off-flavor compounds.</p><h3><strong>3. Thermo Fisher Scientific: Sentinel PRO 710 environmental mass spectrometer Precise real time gas analyzer for toxic volatile organic compounds</strong></h3><ul><li>Product specification</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/sentinel_pro_710_spec_sheet_en_886523bfc2.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=3&amp;search=Sentinel+PRO"><strong>Thermo Scientific™ Sentinel PRO Environmental Mass Spectrometer </strong></a>is a highly reliable and versatile gas analyzer ideal for reporting the presence of toxic VOCs from fugitive emissions in industrial settings to ensure worker safety.&nbsp;</p><h5><strong>Fugitive emissions of toxic VOCs&nbsp;</strong></h5><p>Wherever there is potential danger for fugitive emissions of toxic organic vapors from a chemical production unit, regulating authorities often require plants to keep records of ambient vapor concentrations to protect workers from exposure. Various forms of capture include evacuated vessels, organic vapor monitors, or purge and trap devices, all of which require samples to be sent for analysis. Alternatively, electrochemical sensors or open path FT-IR spectroscopy can provide more immediate results. However, none of these technologies are capable of providing the spatial and temporal resolution required to qualify as actionable information.&nbsp;</p><h5><strong>Analytical platform&nbsp;</strong></h5><p>The primary feature of the Sentinel PRO mass spectrometer is the magnetic sector analyzer. This field-proven technology has demonstrated the strongest performance for industrial on-line gas analysis. Magnetic sector technology offers precision, accuracy, long intervals between calibrations. The new touchscreen interface further enhances usability, providing intuitive in-person operation, simplified maintenance, and real-time data viewing. Multi-role user permissions ensure security and control allowing operators to customize settings based on their specific needs.&nbsp;</p><h5><strong>Comprehensive data collection&nbsp;</strong></h5><p>With speed and precision, the Sentinel PRO analyzer monitors all the critical areas for short-term exposure levels of toxic VOCs, and also provides accurate and time-weighted average exposure data. With a high number of sample points available, many can be located close to potential leak points such as valve stems, etc., enabling leak detection and correction before any toxic hazard is created.&nbsp;</p><h5><strong>Membrane inlet mass spectrometry&nbsp;</strong></h5><p>The analyzer is fitted with a membrane inlet to reduce the pressure of the sample air from atmospheric to the working pressure of the enclosed ion source. This allows a method of sample introduction that greatly enhances the system’s sensitivity to VOCs. Since the membrane is more permeable to VOCs than to major air gases, it provides enrichment by several orders of magnitude, enabling detection as low as 5 ppb (species dependent) permits easy membrane replacement during annual routine maintenance to minimize downtime and increase productivity.</p></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 21, 2026

News from LabRulezLCMS Library - Week 21, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 18th May 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you brochure by<strong> MILESTONE </strong>and<strong> </strong>application notes by<strong> Shimadzu </strong>and <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. MILESTONE: </strong><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?search=ETHOS+LEAN+"><strong>ETHOS™ LEAN</strong></a><strong> Compact Microwave Labstation</strong></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Brochure_ETHOS_LEAN_1_c80f4403a4.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Sample preparation is the foundation of many analytical workflows, and often the most critical step. In elemental analysis, proper digestion ensures accurate and reproducible results with AAS, ICP, and ICP-MS by enabling complete recovery of target elements, minimizing interferences, and reducing blanks. With over 35 years of innovation and more than 30,000 microwave systems installed worldwide, Milestone is a global leader in microwave sample preparation. The ETHOS LEAN, now in its 2nd series, represents this expertise: a compact, affordable labstation delivering full digestion capabilities without compromise. Beyond digestion, ETHOS LEAN supports solvent extraction for chromatography, solvent-free extraction of natural products, and even microwave synthesis workflows, offering unmatched versatility in its class. Selecting the right system is more than a purchase decision: it’s choosing a partner. With Milestone, you gain not only proven technology but also the knowledge and support to ensure long-term success.</p><h4><strong>BUILT FOR MORE THAN DIGESTION</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?search=ETHOS+LEAN+"><strong>ETHOS LEAN</strong></a> goes beyond digestion. As a compact Microwave Labstation, it supports a suite of accessories that expand its capabilities into multiple workflows. Microwave technology provides a faster, cleaner, and more efficient alternative to conventional sample preparation techniques, reducing processing time, simplifying operations, and minimizing reagent consumption.&nbsp;</p><h5><strong>Solvent extraction</strong></h5><p>Closed-vessel microwave technology streamlines extraction for chromatographic analysis, dramatically reducing solvent use and cutting analysis times. Ideal for organic pollutant extraction from environmental samples or fat determination in food and feed.</p><h5><strong>Solvent-free extraction</strong></h5><p>Patented Milestone technology enables fast and efficient essential oil extraction in just minutes, preserving aroma and natural composition while minimizing degradation. Selective heating promotes a quicker, more efficient release from plant cells.</p><h5><strong>Microwave synthesis</strong></h5><p>Microwave synthesis is a safer and faster alternative to heating mantles or complex reactors, enabling rapid optimization of conditions. Its speed supports research projects and allows practical teaching sessions within standard class times.</p><h5><strong>High-temperature processes</strong></h5><p>With the ultraFAST accessory, ETHOS LEAN reaches 1200 °C in just minutes, transforming into a microwave furnace for demanding high-temperature applications such as inorganic synthesis, fusion, or fire assay.</p><h3><strong>2. Shimadzu: Discriminating between Microsamples of Similar Resins with a Combination of FTIR and Thermal Analysis Instruments</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01114_en_a9291de45e.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User Benefits</strong></h4><ul><li>Using the ATR method with FTIR spectroscopy enables simple and rapid qualitative analysis of polymers.</li><li>DSC analysis may be able to reveal differences in polymer thermal histories that cannot be confirmed by FTIR alone.</li><li>TG-DTA can be used to confirm the content level of inorganic additives in polymers</li></ul><p>A wide range of polymer resins is used in modern society for diverse applications, resulting in increasing demand for qualitative analysis of resin microsamples, such as identifying resin contaminants in products or qualitatively evaluating microplastics for environmental impact assessments. FTIR spectrophotometers are commonly used for qualitative analysis of polymers. In particular, the ATR (attenuated total reflectance) method is widely used because measurements can be performed simply and quickly by clamping a sample against a prism to ensure close contact.&nbsp;</p><p>While the ATR method makes it relatively easy to discriminate between different types of polymers, clear differences may not appear when analyzing similar polymers—for example, when there are only slight differences in the type or content of additives or the thermal histories during manufacturing. In such cases, differences may be confirmed by using thermal analysis instruments, such as a DSC or TG-DTA system.&nbsp;</p><p>This article describes an example in which three instruments— an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=IRSpirit-TX"><strong>IRSpirit-TX</strong></a> FTIR spectrophotometer, a <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=DSC-60+Plus"><strong>DSC-60 Plus</strong></a> differential scanning calorimeter, and a DTG-60 simultaneous DTA-TG unit (Fig. 1)—were used to confirm differences among six microsamples of polypropylene (PP) resin.</p><h4><strong>Conclusion</strong></h4><p>Details of the six types of PP resin identified from the above measurement results are shown in Table 4. The results indicate that by using an FTIR spectrophotometer in combination with thermal analysis equipment, such as DSC and TG-DTA systems, it is possible to distinguish between minute amounts of the same type of resin with various different properties.</p><h3><strong>3. Thermo Fisher Scientific: XPS depth profiling of advanced solar cells with femtosecond laser ablation</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/xps_depth_profiling_advanced_solar_cells_appnote_7bda4471a5.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Perovskites are an emerging class of materials in the solar cell industry, exhibiting a number of promising properties, such as improved efficiency and weight, compared to traditional silicon-based devices. X-ray photoelectron spectroscopy (XPS) is an established tool in solar cell research due to its ability to provide extremely surface-sensitive information about elemental composition along with chemical and electronic states.¹ XPS is ultimately a surface analysis technique, however, and in order to assess the full composition of complex, multi-layered structures such as solar cells, a technique known as depth profiling is necessary, which performs multiple rounds of successive material removal and analysis.&nbsp;</p><p>This application note explores a recent study by Chandler et al. that focuses on solar cells designed for aerospace applications,² where accurate determination of the “true” starting composition of the stacks is essential for tests that simulate space conditions, such as radiation exposure. Without a reliable baseline, it becomes impossible to distinguish between changes induced by the experimental conditions and artifacts introduced during analysis. Conventional ion beam sputtering methods used for depth profiling are known to distort chemical information for perovskites; femtosecond laser ablation (fs-LA) is presented as a novel, alternative method that helps to preserve vital chemical information.</p><h4><strong>Experimental</strong></h4><p>A halide-perovskite-based solar cell was fabricated on an ITO/SnO₂ substrate using a spin coating method; the structure of the layers is shown in Figure 1.</p><p>Analysis was performed with the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2206"><strong>Thermo Scientific™ Hypulse™ Surface Analysis System</strong></a>, which is equipped with both traditional ion-beam sputtering and femtosecond-laser ablation capabilities. XPS data was collected in SnapShot acquisition mode using an X-ray spot size of 30-200 µm, depending on the method of depth profiling.&nbsp;</p><p>A MAGCIS ion gun was employed for the sputter depth profiles, generating either a 500 eV monatomic Ar⁺ beam or 8 keV Ar₁₅₀⁺ clusters. The fs-LA depth profiles were generated using a 1,030 nm wavelength laser operating at a 160 fs pulse length. The pulse energy was increased from 42 µJ to 167 µJ when transitioning from the perovskite layer into the substrate structure. A flood gun was employed for charge neutralization during profiling.</p><h4><strong>Summary&nbsp;</strong></h4><p>This study confirms the challenges associated with traditional ion sputtering (both monatomic and cluster) for the depth profiling of perovskite-based solar cells. These methods cause preferential sputtering, particularly of lighter elements like carbon, nitrogen, and iodine, which distorts elemental ratios in the profiles and results in artificial signals, such as the formation of metallic lead (Pb⁰). Depth profiling with femtosecond laser ablation represents a novel and robust alternative that preserves the original chemical composition and oxidation states throughout the perovskite layer. By avoiding preferential removal effects, accurate compositional information is maintained during the profile, and erroneous peak signals associated with chemical reduction are eliminated. These factors are vital in establishing a chemically undisturbed baseline before performing tests that simulate environmental effects on the solar cells.&nbsp;</p><p>With fs-LA depth profiling, any induced changes can be confidently delineated from analytical artifacts, and researchers can better understand and mitigate environmental effects on solar-cell performance, eventually leading to improved solar technologies for aerospace applications.</p>

News from LabRulezICPMS Library - Week 21, 2026

Inline Analysis of the Plastics Melt Emissions in Real Time During Mechanical Recycling Using the SIFT-MS Method

From the Road to the Field: Decoding Chemical Transformation in Aging Tire and Artificial Turf Crumb Rubber

Low-Dimensional Zeotypes Templated by Stacked Cyclic Benzimidazolium Revealed by Electron Crystallography

<p><strong>In the week of May 25, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Restek Corporation: Choosing a Different Carrier Gas in GC and Why are Liners Deactivated</strong></h5><ul><li>Tu, 26.5.2026 14:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6213">Registration</a></li></ul><p>This webinar covers the key considerations when switching to hydrogen or nitrogen.</p><h5><strong>2. GERSTEL: AutoTwister and 4 New Twister Phases: Expanding the SBSE Capabilities</strong></h5><ul><li>We, 27.5.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6157">Registration</a></li></ul><p>In this webinar, Frank Jacobs shows how GERSTEL automates the SBSE workflow with AutoTwister, from extraction through thermal desorption.</p><h5><strong>3. AZoM: Real-Time Raman Gas Analysis for Today’s Power Generation: Natural Gas, Hydrogen Blending, and Fusion</strong></h5><ul><li>We, 27.5.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6206">Registration</a></li></ul><p>Discover how real-time Raman gas analysis supports modern power generation by enabling fast, inline monitoring of natural gas, hydrogen blends, and fusion-related gas streams.</p><h5><strong>4. LECO: Effective Utilization of GC and GCxGC in Battery Materials Characterization</strong></h5><ul><li>We, 27.5.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6190">Registration</a></li></ul><p>Gas chromatography is a powerful tool for volatile and semi-volatile species in battery materials, but its application faces significant challenges.</p><h5><strong>5. AZoM: Analysis Masterclass for Polymer-Based Advanced Materials</strong></h5><ul><li>Th, 28.5.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6194">Registration</a></li></ul><p>In this webinar, you will learn about the analytical techniques and best practices for testing polymer-based advanced materials, from early R&amp;D through to production quality control.</p>

Webinars LabRulezGCMS Week 22/2026

<p><strong>In the week of May 25, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Agilent Technologies: PFAS &amp; Our Planet: Food and Food Contact Materials</strong></h5><ul><li>Tu, 26.5.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6141">Registration</a></li></ul><p>Discover how PFAS regulations and LC-MS/MS workflows are shaping food and packaging analysis, from contamination control to cross-border compliance and emerging global trends.</p><h5><strong>2. Tosoh Bioscience: Integrated and Intensified Downstream Processing on a Single Device</strong></h5><ul><li>Tu, 26.5.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6214">Registration</a></li></ul><p>Discover how Tosoh Bioscience uses Octave™ multi-column chromatography to integrate automated dual-step downstream purification workflows for intensified mAb manufacturing.</p><h5><strong>3. SelectScience: Revealing hidden LNP subpopulations with high-resolution chromatographic techniques</strong></h5><ul><li>Tu, 26.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6189">Registration</a></li></ul><p>As lipid nanoparticle (LNP)-based therapeutics diversify and regulatory expectations for complex nucleic acid products mature, analytical strategies must evolve.</p><h5><strong>4. Phenomenex: Reliable GLP-1 Aggregate Analysis Using Biozen dSEC</strong></h5><ul><li>We, 27.5.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6185">Registration</a></li></ul><p>This webinar provides an exploration of peptide aggregation mechanisms and how SEC can be applied to characterize these critical quality attributes.</p><h5><strong>5. Waters Corporation: Getting pH Right</strong></h5><ul><li>We, 27.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6193">Registration</a></li></ul><p>This webinar covers practical approaches to improving pH measurement accuracy in environmental testing.</p><h5><strong>6. Technology Networks: Ultrashort-Chain PFAS: Practical Guidance for Testing Labs</strong></h5><ul><li>We, 27.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6192">Registration</a></li></ul><p>Environmental labs are facing increasing pressure to address ultrashort-chain PFAS as regulatory scrutiny accelerates and begins to influence current testing priorities.</p><h5><strong>7. Agilent Technologies: Navigating PFAS Complexity: Addressing the Unique Chromatographic Challenges of Ultra-Short-Chain PFAS</strong></h5><ul><li>We, 27.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6191">Registration</a></li></ul><p>In this webinar, we will discuss key considerations for selecting an LC separation technique and choosing appropriate consumables.</p><h5><strong>8. Waters Corporation: Informatics series #32 Empower Data Exchange - Core Features</strong></h5><ul><li>Th, 28.5.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6221">Registration</a></li></ul><p>Master data export in Empower Software. Learn how to create export methods for raw data, results, and reports, ensuring secure data transfer into applications like LIMS or NuGenesis.</p><h5><strong>9. Waters Corporation: Transform Your Daily Lab Operations with Automation - Pharma Workflows</strong></h5><ul><li>Th, 28.5.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6219">Registration</a></li></ul><p>Explore automated pharma workflows that reduce variability, improve efficiency, and support compliant multistep sample preparation.</p><h5><strong>10. Separation Science: Connecting Microbiology and Toxicology: LC-MS/MS Methods for Cereulide Quantitation in Food Matrices</strong></h5><ul><li>Th, 28.5.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6215">Registration</a></li></ul><p>Learn how LC-MS/MS enables sensitive cereulide detection in infant formula, ARA oil, and dairy products, addressing critical food safety gaps missed by standard microbiological screening.</p><h5><strong>11. Thermo Fisher Scientific: Modern approach to analyze disinfection by-products in water</strong></h5><ul><li>Th, 28.5.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6217">Registration</a></li></ul><p>Discover how IC-MS is transforming disinfection by-products analysis and helping laboratories stay ahead of evolving regulatory demands. Explore the future of efficient and accurate water quality testing.</p><h5><strong>12. Waters Corporation: Is your Biosimilar, Similar?</strong></h5><ul><li>Th, 28.5.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6216">Registration</a></li></ul><p>Explore regulatory expectations and advanced SEC-MALS workflows for biosimilarity assessment of monoclonal antibodies, including CQAs, aggregation analysis, and impurity profiling.</p><h5><strong>13. Evosep Biosystems: Preparing for Next Generation Evosep Proteomics</strong></h5><ul><li>Th, 28.5.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6196">Registration</a></li></ul><p>Get an exclusive pre-ASMS 2026 sneak peek into how Evosep is driving the next phase of proteomics standardization, showcasing advancements in Evotip-based sample prep and integrated workflows.</p><h5><strong>14. Waters Corporation: Purifying Problematic Compounds by RP-LC: Simplified Workflows for Better Outcomes with Inert Preparative Columns</strong></h5><ul><li>Th, 28.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6220">Registration</a></li></ul><p>Optimize Prep LC workflows for compounds prone to metal interactions. Discover how Waters MaxPeak Premier Columns increase purity and target recovery.</p><h5><strong>15. Unchained Labs: Break the protein formulation code with Aunty</strong></h5><ul><li>Th, 28.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6218">Registration</a></li></ul><p>Speed up protein formulation studies with Aunty. Join this webinar to learn how high-throughput DSF, SLS, and DLS can optimize workflow and improve efficiency.</p><h5><strong>16. SelectScience: Powering reliable industrial analysis with advanced C-IC workflows</strong></h5><ul><li>Fr, 29.5.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6225">Registration</a></li></ul><p>Learn how combustion ion chromatography (C-IC) simplifies halogen and sulfur analysis in complex matrices using the Thermo Scientific Cindion C-IC system and new LPG/Gas module.</p><h5><strong>17. SelectScience: TechTalk: Smarter LC investments that improve efficiency in biopharma labs</strong></h5><ul><li>Fr, 29.5.2026 16:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6222">Registration</a></li></ul><p>Discover how Agilent Infinity III LC Series innovations enhance efficiency in biopharma labs. Learn to combine HPLC/UHPLC robustness with new capabilities to streamline workflows in 20 minutes.</p><h5><strong>18. SelectScience: Advancing PFAS biomonitoring: What we measure and why it matters</strong></h5><ul><li>Fr, 29.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6036">Registration</a></li></ul><p>Explore how advanced LC-MS/MS, HRMS, and multi-omics reshape PFAS biomonitoring and health-risk assessment. Expert panel connects analytical science with clinical and regulatory decision-making.</p>

Webinars LabRulezLCMS Week 22/2026

<p><strong>In the week from May 25, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. SelectScience: Revealing hidden LNP subpopulations with high-resolution chromatographic techniques</strong></h5><ul><li>Tu, 26.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6189">Registration</a></li></ul><p>As lipid nanoparticle (LNP)-based therapeutics diversify and regulatory expectations for complex nucleic acid products mature, analytical strategies must evolve.</p><h5><strong>2. Mettler-Toledo: Continuous Flow Process Optimization and Control</strong></h5><ul><li>We, 27.5.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4651">Registration</a></li></ul><p>Novel developments in continuous flow reactor technologies, advantages over batch processes, and PAT for rapid analysis, optimization, and scale-up.</p><h5><strong>3. AZoM: Real-Time Raman Gas Analysis for Today’s Power Generation: Natural Gas, Hydrogen Blending, and Fusion</strong></h5><ul><li>We, 27.5.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6206">Registration</a></li></ul><p>Discover how real-time Raman gas analysis supports modern power generation by enabling fast, inline monitoring of natural gas, hydrogen blends, and fusion-related gas streams.</p><h5><strong>4. Milestone: Total fat, FAMEs, and amino acids: modern sample prep workflows for nutritional analysis</strong></h5><ul><li>We, 27.5.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6159">Registration</a></li></ul><p>Discover modern microwave-based workflows for total fat, FAMEs, and amino acid analysis, enabling faster, safer, and more reproducible nutritional testing.</p><h5><strong>5. AZoM: Analysis Masterclass for Polymer-Based Advanced Materials</strong></h5><ul><li>Th, 28.5.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6194">Registration</a></li></ul><p>In this webinar, you will learn about the analytical techniques and best practices for testing polymer-based advanced materials, from early R&amp;D through to production quality control.</p><h5><strong>6. Mettler-Toledo: Thermal Analysis in the Food Industry</strong></h5><ul><li>Th, 28.5.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5774">Registration</a></li></ul><p>Discover how thermal analysis techniques like DSC, TGA, TMA, and DMA are used to characterize food products and packaging across processing, storage, and quality control.</p><h5><strong>7. Unchained Labs: Break the protein formulation code with Aunty</strong></h5><ul><li>Th, 28.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6218">Registration</a></li></ul><p>Speed up protein formulation studies with Aunty. Join this webinar to learn how high-throughput DSF, SLS, and DLS can optimize workflow and improve efficiency.</p><h5><strong>8. SPECTRO Analytical Instruments: Reliable EN 71-3 Toy Safety Testing Using the SPECTROGREEN MS</strong></h5><ul><li>Th, 28.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6211">Registration</a></li></ul><p>Discover how ICP-MS analysis with the SPECTROGREEN MS enables reliable EN 71-3 compliant toy safety testing for trace-level elemental impurities in plastics, rubbers, and inks.</p><h5><strong>9. Agilent Technologies: Elemental Analysis in Jet Fuel with ICP-MS and ICP-QQQ</strong></h5><ul><li>Th, 28.5.2026 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6064">Registration</a></li></ul><p>This presentation will showcase direct injection of jet fuel in ICP-MS without any sample preparations for elemental analysis, with detection limits in parts-per-billion levels.</p>

Webinars LabRulezICPMS Week 22/2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 25th May 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application note by<strong> Shimadzu, </strong>presentation by <strong>MDCW / University of Washington</strong> and poster by <strong>Waters Corporation!</strong></p><h3><strong>1. MDCW / University of Washington: Implementing Tile-Based Fisher Ratio Analysis of GC×GC-TOFMS Data to Obtain a Master Peak Table of All Detected Analyte Compounds in Many Petroleum-Based Samples</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_9_Halvorsen_136808e314.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>This presentation describes the development of a new chemometric workflow for processing <strong>GC×GC-TOFMS (comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry)</strong> data from petroleum-derived fuels. The work was conducted by researchers from the University of Washington in collaboration with Chevron Technical Center and focuses on creating a comprehensive <strong>Master Peak Table (MPT)</strong> containing all detectable analytes across multiple fuel sample classes. The motivation was that moving from conventional GC to GC×GC dramatically increased chromatographic peak capacity and resolution, but also created a need for more sophisticated data analysis methods capable of handling the much larger number of detected compounds.</p><p>The analytical platform employed <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37"><strong>GC×GC-TOFMS</strong></a> with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1289"><strong>thermal-flow modulator</strong></a> and a TOF mass spectrometer detector. Fuel samples were analyzed using an <strong>Rxi-1 column (30 m × 0.25 mm × 0.25 μm)</strong> in the first dimension and an <strong>Rxi-17MS column (2.0 m × 0.18 mm × 0.20 μm)</strong> in the second dimension. The sample set included multiple petroleum products such as hydrobates, reformates, naphthas, FCC gasoline, and blank samples. Log-scale chromatograms revealed numerous late-eluting trace compounds and significant compositional differences between fuel batches that were not readily visible in conventional chromatographic representations.</p><p>To process these highly complex datasets, the researchers implemented a <strong>tile-based Fisher Ratio (F-ratio) chemometric approach</strong> using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348"><strong>ChromaTOF Tile software</strong></a>. The method divides GC×GC chromatograms into small tiles and identifies regions where analyte signals differ significantly between sample classes by comparing between-class and within-class variance. Instead of relying solely on F-ratio ranking, the workflow incorporates statistical testing against blank samples. Three blank chromatograms were used to establish tile-specific confidence intervals and p-test thresholds, allowing the system to determine whether detected signals represent genuine compounds rather than background noise. This strategy enabled the creation of a unified master peak table while minimizing problems caused by retention-time shifts and reducing the need for manual user intervention.</p><p>Application of the method generated <strong>719 statistically significant analyte hits</strong> across the fuel classes and demonstrated excellent reproducibility, with only <strong>6.3% of classifications showing inconsistent behavior among replicates</strong>. Detected compounds included hydrocarbons and aromatic species such as <strong>1-methylnaphthalene, 1,2,4-trimethylbenzene, β-vatirenene, 2-octene, and tetramethylheptadecane</strong>, whose occurrence patterns aligned well with expected fuel chemistry. The resulting master peak table contained both shared and sample-specific compounds and provided a much more comprehensive representation of petroleum composition than conventional workflows. The authors conclude that the approach should be broadly applicable to other complex sample types and could be extended using alternative chemometric metrics beyond Fisher Ratio analysis to address different experimental objectives.</p><h3><strong>2. Shimadzu: A Simple Method for Determination of β-Sitosterol as a Marker of Vegetable Oil Adulteration in Ghee by GC</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_06_sip_gc_042_en_f4c307005b.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>ShimadzuNexis GC-2030 can be effectivelyused for determination of adulteration of Ghee with vegetable oil.</li><li>The NexisGC-2030 easily meets the acceptancecriteria as per the proposed FSSAI method no.01.097:2022.</li><li>This method is suitable for routine food industry analysis and academic research.</li></ul><p>The most common milk product in Indian cuisine is ghee or clarified butter. Due to its high cost, ghee is adulterated with vegetable oil, to gain commercial benefits. β-sitosterol, a common phytosterol, found in a variety of natural sources, including vegetable fat or oil from plants (Figure 1). It is used as a marker of vegetable oil adulteration in ghee<sup>1</sup>.</p><p>The primary goal of this study is to assess the vegetable oil adulteration in ghee by analyzing β-Sitosterol as a marker using gas chromatography (GC). This will establish a foundation for the rapid detection of ghee adulteration. In this study, a simple, sensitive, and inexpensive method is developed for extraction of β-Sitosterol from ghee which is then subjected to gas chromatography with flame ionization detection for quantitation. The effects of several important parameters influencing the extraction efficiencies of β-Sitosterol including water-immiscible organic solvent (type and volume), volume of water, sonication time, surfactant (type and concentration), and organic modifier (type and volume) were investigated. This method is ideal for routine analysis in the food industry during the manufacturing, processing, and commercial testing of milk fat samples, or for academic research purposes.</p><h4><strong>&nbsp;Sample Preparation and Analysis Conditions</strong></h4><p>Standard and sample preparations were conducted following the guidelines outlined in the proposed FSSAI method No. 01.097:20222. The analysis was performed using a Shimadzu <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2030"><strong>Nexis GC-2030</strong></a> equipped with a Flame Ionization Detector (FID), as shown in Figure 2. The specific configuration and analytical conditions used during the study are provided in Table 1.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>A gas chromatography–based method using GC-2030 was developed for the estimation of β-Sitosterol in ghee. The method exhibits a detection limit of 2 %, enabling the identification of vegetable oil adulteration in ghee at levels as low as 2 %. At this adulteration level, the signal of β-Sitosterol achieved a signal-to-noise (S/N) greater than 3, confirming the reliability of detection at the established limit. This method provides a reliable and effective approach for the quantification of β-Sitosterol, which serves as a marker for vegetable oil adulteration in ghee.</p><h3><strong>3. Waters Corporation: Multidimensional Characterization of Short Chain Chlorinated Paraffins (SCCPs) with GC-APCI and Cyclic Ion Mobility</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009386_3232568115.pdf"><strong>Full PDF for download</strong></a></li></ul><p>This poster presents a multidimensional analytical approach for the characterization of <strong>short-chain chlorinated paraffins (SCCPs)</strong>, a class of persistent environmental pollutants included in the Stockholm Convention due to their environmental persistence and bioaccumulation potential. SCCPs are highly complex mixtures of chlorinated hydrocarbons containing thousands of possible congeners, making their analysis particularly challenging. The study evaluates the use of <strong>gas chromatography coupled with atmospheric pressure chemical ionization, cyclic ion mobility spectrometry, and high-resolution mass spectrometry (GC-APCI-IMS-HRMS)</strong> as a powerful platform for improved SCCP characterization.</p><p>The analytical instrumentation consisted of a modified <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890"><strong>Agilent 8890 gas chromatograph</strong></a> equipped with an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=7&amp;search=Rxi-5SilMS"><strong>Rxi-5SilMS capillary column</strong></a><strong> (30 m × 0.25 mm × 0.25 μm)</strong> and connected to a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/202"><strong>Waters SELECT SERIES Cyclic IMS</strong></a><strong> high-resolution mass spectrometer</strong> using an <strong>Atmospheric Pressure GC (APGC) ion source</strong>. Unlike conventional electron ionization methods, APCI was operated in negative-ion mode with a chloroform modifier, promoting the formation of characteristic <strong>[M+Cl]⁻ molecular ions</strong>. This significantly reduced fragmentation and provided strong molecular-ion signals, improving both qualitative identification and quantitative analysis of SCCP homologues.</p><p>Using three commercial SCCP technical mixtures (51.5%, 55%, and 63% chlorine content), the researchers demonstrated that GC-APCI-HRMS could selectively detect SCCP homologues according to carbon-chain length and degree of chlorination. Although substantial chromatographic overlap was observed among many homologues, the addition of <strong>ion mobility spectrometry (IMS)</strong> introduced a valuable extra separation dimension. Distinct drift-time versus m/z trendlines were observed for compounds sharing the same number of chlorine atoms, allowing homologues to be grouped and characterized more effectively than by chromatographic retention and mass spectrometry alone. The IMS data also enabled estimation of the relative abundance of individual homologue groups within each technical mixture.</p><p>The authors further explored the resolving power of the <strong>cyclic IMS device</strong> by employing multiple ion-mobility passes (up to eight cycles) to investigate individual SCCP congeners. While complete separation of individual congeners within a homologue group was not achieved, higher ion-mobility resolution revealed measurable differences between early- and late-eluting species and provided additional insight into compositional differences among SCCP mixtures. The study concludes that combining <strong>GC-APCI, cyclic ion mobility spectrometry, and high-resolution mass spectrometry</strong> offers a powerful multidimensional workflow for the characterization of complex chlorinated paraffin mixtures and may improve environmental monitoring and future regulatory analysis of these challenging contaminants.</p></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 22, 2026

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