Enhanced Host Cell Protein Identification and Quantitation with Multi-Reflecting ToF LC-MS

Application Note An Efficient LC/MS Workflow for Identification and Monitoring of Host Cell Proteins for Assisting Monoclonal Antibody Process Development Catalin E. Doneanu, Michael Daly, Ying Qing Yu Waters Corporation Abstract This application note introduced two analytical workflows for LC-MS…

Application Note Advanced Monoclonal Antibody Peptide Mapping Using Multi-Reflecting TOF MS Technology Jonathan Fox, Ying Qing Yu, Scott J. Berger, Nick Pittman Waters Corporation This is an Application Brief and does not contain a detailed Experimental section. Abstract Peptide mapping…

[ APPLICATION NOTE ] A Comprehensive Approach for HCP Identification, Quantification, and Monitoring Based on a Single Dimension (1D) LC Separation Catalin Doneanu, 1 Sarah Lennon, 2 Malcolm Anderson, 2 Ian Reah, 3 Mal Ross, 3 Steven Anderson, 3 Ian…

DATA INDEPENDENT LC-MS ASSAYS FOR IDENTIFICATION, QUANTIFICATION AND MONITORING OF HOST CELL PROTEINS IN MONOCLONAL ANTIBODIES Catalin Doneanu, Michael Daly, Sean Wu, Scott Berger and Ying Qing Yu Waters Corporation, Milford, MA, USA OVERVIEW HCP Discovery Assay (3B) HCP Monitoring…