An Efficient LC/MS Workflow for Identification and Monitoring of Host Cell Proteins for Assisting Monoclonal Antibody Process Development

AN EFFICIENT LC-MS WORKFLOW FOR IDENTIFICATION AND MONITORING OF HOST CELL PROTEINS FOR ASSISTING MONOCLONAL ANTIBODY PURIFICATION Catalin Doneanu1, Malcolm Anderson2, Alex Xenopoulos3, Romas Skudas4, Ying Qing Yu1, Asish Chakraborty1 and Weibin Chen1 1 Waters Corporation, Milford, MA, USA;2Waters Corporation,…

DATA INDEPENDENT LC-MS ASSAYS FOR IDENTIFICATION, QUANTIFICATION AND MONITORING OF HOST CELL PROTEINS IN MONOCLONAL ANTIBODIES Catalin Doneanu, Michael Daly, Sean Wu, Scott Berger and Ying Qing Yu Waters Corporation, Milford, MA, USA OVERVIEW HCP Discovery Assay (3B) HCP Monitoring…

An Efficient Workflow for Identification and Monitoring of Host Cell Proteins During Monoclonal Antibody Bioprocessing Catalin Doneanu1, Malcolm Anderson2, Alex Xenopoulos3, Romas Skudas4, Ying Qing Yu1, Asish Chakraborty1, Mark Bennett1 and Weibin Chen1 1 Waters Corporation, Milford, MA; 2 Waters…

[ APPLICATION NOTE ] A Comprehensive Approach for HCP Identification, Quantification, and Monitoring Based on a Single Dimension (1D) LC Separation Catalin Doneanu, 1 Sarah Lennon, 2 Malcolm Anderson, 2 Ian Reah, 3 Mal Ross, 3 Steven Anderson, 3 Ian…