Determination of Purity, Assay, and Impurity Profile for a Ligand-Conjugated Antisense Oligonucleotide

Technical Overview Biopharma Purity, Assay, and Impurity Profiling of Single-Stranded Oligonucleotides Using Agilent Oligo Analysis Accelerator for OpenLab CDS Authors Brian Rivera Agilent Technologies, Inc. Introduction Challenges with therapeutic synthetic oligonucleotides include determining the sample purity, label claim or assay,…

Application Note Automated LC/MS Quality Control of Anti-Sense Oligonucleotides Using purpose-built software and high-sensitivity single quadrupole detection Authors Brian Rivera, Lee Bertram Agilent Technologies, Inc. Abstract Antisense oligonucleotides (ASOs) are a complex class of therapeutic nucleic acids that require precise…

Application Note Biopharma Assessing the Purity of an Antisense Oligonucleotide Sample by LC/MS Using a high-sensitivity unit mass detector Authors Abstract Lee Bertram and Brian Rivera Agilent Technologies, Inc. This application note outlines a method for assessing the purity of…

Application Note Workflow for Profiling Impurities in Synthetic Oligonucleotides Using the BioAccord™ LCMS System with waters_connect™ Informatics Kellen DeLaney, Jo-Anne Riley, Jonathan Fox, Heidi Gastall, Laetitia Denbigh, Ying Qing Yu Waters Corporation This is an Application Brief and does not…