Assessing the Purity of an Antisense Oligonucleotide Sample by LC/MS

Application Note Automated LC/MS Quality Control of Anti-Sense Oligonucleotides Using purpose-built software and high-sensitivity single quadrupole detection Authors Brian Rivera, Lee Bertram Agilent Technologies, Inc. Abstract Antisense oligonucleotides (ASOs) are a complex class of therapeutic nucleic acids that require precise…

Table of contents Fast Track to Certainty: Confident Biopharma Decisions with LC-Single Quadrupole Mass Detection How single quadrupole LC/MS simplifies identification, purification, and stability assessment in biopharma Table of Contents Introduction��������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������� 3 Consolidating Biopharma QC Workflows: LC/UV Versus Single Quadrupole…

Application Note Biopharma Analysis of Oligonucleotides Using Ion-Pairing Alternatives on the Agilent Pro iQ Plus Authors Lee Bertram and Brian Rivera Agilent Technologies, Inc. Abstract This application note presents a practical approach for medium- to high-throughput molecular confirmation of synthetic…

Application Note Biopharma Determination of Purity, Assay, and Impurity Profile for a Ligand-Conjugated Antisense Oligonucleotide Using Agilent Oligo Analysis Accelerator for OpenLab CDS Authors James Webster AstraZeneca Macclesfield, United Kingdom Brian Rivera Agilent Technologies, Inc. Santa Clara, CA, United States…