Automated LC/MS Quality Control of Anti-Sense Oligonucleotides

Application Note Biopharma Assessing the Purity of an Antisense Oligonucleotide Sample by LC/MS Using a high-sensitivity unit mass detector Authors Abstract Lee Bertram and Brian Rivera Agilent Technologies, Inc. This application note outlines a method for assessing the purity of…

Technical Overview Biopharma Purity, Assay, and Impurity Profiling of Single-Stranded Oligonucleotides Using Agilent Oligo Analysis Accelerator for OpenLab CDS Authors Brian Rivera Agilent Technologies, Inc. Introduction Challenges with therapeutic synthetic oligonucleotides include determining the sample purity, label claim or assay,…

Application Note Biopharma Determination of Purity, Assay, and Impurity Profile for a Ligand-Conjugated Antisense Oligonucleotide Using Agilent Oligo Analysis Accelerator for OpenLab CDS Authors James Webster AstraZeneca Macclesfield, United Kingdom Brian Rivera Agilent Technologies, Inc. Santa Clara, CA, United States…

Table of contents Fast Track to Certainty: Confident Biopharma Decisions with LC-Single Quadrupole Mass Detection How single quadrupole LC/MS simplifies identification, purification, and stability assessment in biopharma Table of Contents Introduction��������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������� 3 Consolidating Biopharma QC Workflows: LC/UV Versus Single Quadrupole…