TIDES: ANALYSIS OF mRNA CRITICAL QUALITY ATTRIBUTES (CQAs) USING THE BIOACCORD UPLC-TOF MS SYSTEM AND INTACT Mass SOFTWARE

MRNA CRITICAL QUALITY ATTRIBUTE ANALYSIS USING A UPLC-TOF-MS SYSTEM AND CUSTOMIZED SOFTWARE Ying-Qing Yu; Rebecca J. D'Esposito; Catalin E Doneanu; Leslie Napoletano; Michael Zagieboylo Waters Corporation, Milford USA 01757 RESULTS INTRODUCTION Recent development and approval of the two COVID mRNA-based…

Application Note LC-MS Analysis of Two mRNA Critical Quality Attributes: 5’-Capping Efficiency and Average Poly(A) Tail Length and Heterogeneity Using the Xevo™ MRT Mass Spectrometer Catalin Doneanua, Alexandre F. Gomesa, Jo-Anne Rileyb, Ying Qing Yua a Waters Corporation, United States…

Application Note Oligo Mapping of mRNA Digests Using a Novel Informatics Workflow Catalin E. Doneanu, Chris Preston, Matt Gorton, Tatiana Johnson, Bala Addepalli, Ying Qing Yu Waters Corporation Abstract Recent advances in LC-MS and informatics technologies are supporting scientists in…

Application Note Head to Tail Analysis of mRNA by RapiZyme™ MC1 and Cusativin Alexandre F. Gomes*, Tatiana Johnston*, Balasubrahmanyam Addepalli * Equal contribution Waters Corporation, United States Published on August 10, 2026 Abstract Head to Tail Analysis of mRNA by…