MRNA CRITICAL QUALITY ATTRIBUTE ANALYSIS USING A UPLC-TOF-MS SYSTEM AND CUSTOMIZED SOFTWARE

ANALYSIS OF mRNA CRITICAL Q QUALITY ATTRIBUTES ( (CQAs) Q ) USING THE BIOACCORD UPLC-TOF MS SYSTEM AND INTACT Mass SOFTWARE Rebecca D’Esposito D Esposito1, Catalin Doneanu1, Heidi Gastall2, Scott JJ. Berger1, and Ying Qing Yu1 1 W t C…

Application Note LC-MS Analysis of Two mRNA Critical Quality Attributes: 5’-Capping Efficiency and Average Poly(A) Tail Length and Heterogeneity Using the Xevo™ MRT Mass Spectrometer Catalin Doneanua, Alexandre F. Gomesa, Jo-Anne Rileyb, Ying Qing Yua a Waters Corporation, United States…

SOFTWARE TOOLS FOR AUTOMATED LC/MS ANALYSIS OF CRITICAL QUALITY ATTRIBUTES OF mRNA MOLECULES Catalin Doneanu1, Alexandre F. Gomes1, Jo-Anne Riley2, Chris Preston2, Matt Gorton2, Tatiana Johnston1, Bala Addepalli1, and Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation,…

Application Note Sequence Mapping of mRNA Digests Using the Xevo™ MRT Mass Spectrometer and waters_connect™ MAP Sequence 2.0 Application Catalin Doneanu, Alexandre F. Gomes, Chris Preston, Matt Gorton, Tatiana Johnston, Bala Addepalli, Ying Qing Yu Waters Corporation, United States Published…