Application Note Quantifying Oligonucleotide Deamination with Multi-Reflecting Time-of-Flight Mass Spectrometry Jo-Anne Riley, Jonathan Fox, Laetitia Denbigh, Scott Berger, Nick Pittman, Ying Qing Yu Waters Corporation, United States Published on September 09, 2025 Abstract In this study, the identification and quantification…
CONFIRM Sequence - A NEW SOFTWARE TOOL FOR SEQUENCE CONFIRMATION AND IMPURITY ANALYSIS OF SYNTHETIC OLIGONUCLEOTIDES Catalin Doneanu1, Mathew Gorton2, Chris Knowles2, Ian Morns3, Chris Preston3, Ian Reah3, Mike Broughton3, Simon Jones3, Jonathan Rewcastle3, Rory Mullins3, Edvinas Karmonas3, Paul Henesey3,…
AUTOMATED WORKFLOWS FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES Catalin Doneanu1, Chris Knowles2, Mathew Gorton3, Joseph Fredette1, Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, United Kingdom; 3Waters Corporation, Newcastle upon Tyne, United Kingdom…
Application Note A Xevo™ G3-based Workflow for Purity Determination, Intact Mass Measurement, and MS/MS Sequencing of Impurities Detected in Synthetic Oligonucleotides Catalin E. Doneanu, Jonathan Fox, Brad J. Williams, Chris Knowles, Ying Qing Yu Waters Corporation Abstract This study evaluates…
