Quantifying Oligonucleotide Deamination with Multi-Reflecting Time-of-Flight Mass Spectrometry

INVESTIGATION OF OLIGONUCLEOTIDE DEAMINATION USING HIGH-RESOLUTION MASS SPECTROMETRY Jo-Anne Riley1, Jonathan Fox1 , Laetitia Denbigh1, Catalin Doneanu2, Nick Pittman1, and Ying Qing Yu2 1 Waters Corporation, Wilmslow, UK; 2Waters Corporation, Milford MA, USA; FLP only (control for 0.10% deamination) INTRODUCTION…

Application Note Advanced Oligonucleotide Characterization Using Multi-Reflecting Time-of-Flight Technology Jonathan Fox1, Ying Qing Yu1, Scott J Berger1, Nick Pittman1 1 Waters corporation, United States Published on May 02, 2025 Abstract LC-MS has become a widely used analytical tool for oligonucleotide…

High Performance Liquid Chromatograph Mass Spectrometer Application News Analysis of Oligonucleotide Impurities Using Single Quadrupole Mass Spectrometer Mizuki Hayakawa, Hiroyuki Niwa User Benefits  Combination use of LCMS-2050 single quadrupole mass spectrometer and LabSolutions Insight Biologics provides comprehensive characterization of…

Application Note Oligo Mapping of sgRNA Digests: Leveraging Xevo MRT Mass Spectrometer Performance and Streamlining Data Analysis Catalin Doneanu, Alexandre F Gomes, Tatiana Johnston, Chris Preston, Matt Gorton, Bala Addepalli, Scott Berger, Ying Qing Yu Waters Corporation, Milford, MA, United…