CONFIRM Sequence - A NEW SOFTWARE TOOL FOR SEQUENCE CONFIRMATION AND IMPURITY ANALYSIS OF SYNTHETIC OLIGONUCLEOTIDES

AN AUTOMATED WORKFLOW FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF SYNTHETIC OLIGONUCLEOTIDES AND THEIR IMPURITIES Catalin Doneanu1, Chris Knowles2, Matthew Gorton2, Joe Fredette1 and Ying Qing Yu1 1 Waters Corporation, Milford, MA USA; 2Waters Corporation, Wilmslow, UK RESULTS OVERVIEW…

AUTOMATED WORKFLOWS FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES Catalin Doneanu1, Chris Knowles2, Mathew Gorton3, Joseph Fredette1, Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, United Kingdom; 3Waters Corporation, Newcastle upon Tyne, United Kingdom…

Application Note CONFIRM Sequence: A waters_connect™ Application for Sequencing of Synthetic Oligonucleotides and Their Impurities Catalin E. Doneanu, Chris Knowles, Matt Gorton, Henry Shion, Joseph Fredette, Ying Qing Yu Waters Corporation Abstract This application note demonstrates an automated, compliance-ready liquid…

ANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON THE BIOACCORD LC-MS SYSTEM WITH ACQUITY PREMIER Catalin Doneanu1, Christopher Knowles2, Jonathan Fox2, Emma Harry2, Ying Qing Yu1, Joseph Fredette1, Ann Grey1 and Weibin Chen1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, UK;…