PAMS: AUTOMATED WORKFLOWS FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES

CONFIRM Sequence - A NEW SOFTWARE TOOL FOR SEQUENCE CONFIRMATION AND IMPURITY ANALYSIS OF SYNTHETIC OLIGONUCLEOTIDES Catalin Doneanu1, Mathew Gorton2, Chris Knowles2, Ian Morns3, Chris Preston3, Ian Reah3, Mike Broughton3, Simon Jones3, Jonathan Rewcastle3, Rory Mullins3, Edvinas Karmonas3, Paul Henesey3,…

AN AUTOMATED WORKFLOW FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF SYNTHETIC OLIGONUCLEOTIDES AND THEIR IMPURITIES Catalin Doneanu1, Chris Knowles2, Matthew Gorton2, Joe Fredette1 and Ying Qing Yu1 1 Waters Corporation, Milford, MA USA; 2Waters Corporation, Wilmslow, UK RESULTS OVERVIEW…

Application Note CONFIRM Sequence: A waters_connect™ Application for Sequencing of Synthetic Oligonucleotides and Their Impurities Catalin E. Doneanu, Chris Knowles, Matt Gorton, Henry Shion, Joseph Fredette, Ying Qing Yu Waters Corporation Abstract This application note demonstrates an automated, compliance-ready liquid…

ANALYSIS OF OLIGONUCLEOTIDE IMPURITIES ON THE BIOACCORD LC-MS SYSTEM WITH ACQUITY PREMIER Catalin Doneanu1, Christopher Knowles2, Jonathan Fox2, Emma Harry2, Ying Qing Yu1, Joseph Fredette1, Ann Grey1 and Weibin Chen1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, UK;…