A Robust Workflow for Biosimilar Comparability Assessment via Intact and Subunit RPLC-MS and Native IEX-MS with the Xevo G3 QTof MS Platform

MP012 A Robust Workflow for Biosimilar Comparability Assessment via Intact and Subunit RPLC-MS and Native IEX-MS with a Prototype Benchtop QTOF Charge Variant Analysis (IEX-MS) Samantha Ippoliti1; Owen Cornwell2; Lisa Reid2; Ying Qing Yu1; Emma Harry2; Scott Berger1; 1Waters Corporation,…

Application Note Comprehensive Biosimilar Comparability Assessment via Intact and Subunit RP-MS and IEX-UV-MS Using the Xevo™ G3 QTof System Samantha Ippoliti, Owen Cornwell, Lisa Reid, Ying Qing Yu, Emma Harry, Mark Towers Waters Corporation Abstract With the increasing prevalence of…

Application Note Applying Peptide Mapping and MultiAttribute Method (MAM) Workflow for Biosimilar mAb Drug Products Comparison on the Xevo™ G3 QTof Platform Kellen DeLaney, Samantha Ippoliti, Lisa Reid, Owen Cornwell, Ying Qing Yu, Emma Harry, Mark Towers Waters Corporation Abstract…

[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…