Applying Peptide Mapping and Multi- Attribute Method (MAM) Workflow for Biosimilar mAb Drug Products Comparison on the Xevo™ G3 QTof Platform

PEPTIDE CHARACTERIZATION AND MONITORING WORKFLOW FOR BIOSIMILAR mAb DRUG PRODUCTS USING A COMPLIANCE READY LC-MS AND INFORMATICS PLATFORM 20221115_Remicade T0_200ng_03 2 TOF MSe (50 2000) 6V ESI (BPI) 1/2 20221115_Inflectra T0_200ng_12 2 TOF MSe (50 2000) 6V ESI (BPI) Kellen…

[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…

Biosimilar Peptide Mapping Characterization and MAM Workflow Using Prototype Benchtop QTOF with an App-Based Acquisition and Data Processing Platform Kellen DeLaney1, Samantha Ippoliti1; Lisa Reid2; Owen Cornwell2; Ying Qing Yu1; Emma Harry2; Scott Berger1 1Waters Corporation, Milford, Massachusetts; 2Waters Corporation,…

Biosimilar Peptide Mapping Characterization and MAM Workflow Using Prototype Benchtop QTOF with an App-Based Acquisition and Data Processing Platform Kellen DeLaney1, Samantha Ippoliti1; Lisa Reid2; Owen Cornwell2; Ying Qing Yu1; Emma Harry2; Scott Berger1 1Waters Corporation, Milford, Massachusetts; 2Waters Corporation,…