CONFIRM Sequence: A waters_connect Application for Sequencing of Synthetic Oligonucleotides and Their Impurities

Application Note A Xevo™ G3-based Workflow for Purity Determination, Intact Mass Measurement, and MS/MS Sequencing of Impurities Detected in Synthetic Oligonucleotides Catalin E. Doneanu, Jonathan Fox, Brad J. Williams, Chris Knowles, Ying Qing Yu Waters Corporation Abstract This study evaluates…

CONFIRM Sequence - A NEW SOFTWARE TOOL FOR SEQUENCE CONFIRMATION AND IMPURITY ANALYSIS OF SYNTHETIC OLIGONUCLEOTIDES Catalin Doneanu1, Mathew Gorton2, Chris Knowles2, Ian Morns3, Chris Preston3, Ian Reah3, Mike Broughton3, Simon Jones3, Jonathan Rewcastle3, Rory Mullins3, Edvinas Karmonas3, Paul Henesey3,…

A WORKFLOW FOR PURITY DETERMINATION, INTACT MASS MEASUREMENT AND MS/MS SEQUENCING OF OLIGONUCLEOTIDE IMPURITIES DETECTED IN SYNTHETIC OLIGOS Catalin Doneanu1, Jonathan Fox2, Brad J. Williams1, Chris Knowles3, Scott Berger1and Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation,…

AUTOMATED WORKFLOWS FOR INTACT MASS, PURITY AND SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES Catalin Doneanu1, Chris Knowles2, Mathew Gorton3, Joseph Fredette1, Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation, Wilmslow, United Kingdom; 3Waters Corporation, Newcastle upon Tyne, United Kingdom…