Tandem Quadrupole DESI Imaging To Visualize Spatial Distribution of Gefitinib and Related Metabolites in Rat Liver Anthony J. Midey,1 Robert Plumb,1 Nikunj Tanna,1 and Ian D. Wilson2 1Waters Corp., Milford, MA, USA; 2Imperial College London, London, UK Study Design Samples…
Application Note A Streamlined Workflow for Quantitative Bioanalysis using waters_connect for Quantitation Software: A Case Study Using Gefitinib Robert Plumb Waters Corporation, United States Published on November 20, 2025 Abstract Preclinical and early human drug metabolism and pharmacokinetics (DMPK) studies…
Application Note A Rapid UPLC™-MS/MS Method for the Quantification of PROTACs-3-Gefitinib and Urinary Metabolites Following Subcutaneous Administration to Male Rats Robert S. Plumb, Nikunj Tanna Waters Corporation Abstract Proteolysis Targeting Chimera (PROTAC) drugs are now well established in pharmaceutical development…
Application Note Rapid, High Sensitivity Quantification of a Proteolysis Targeting Chimera, PROTAC, in Rat Plasma From a Microsampling DMPK Study Using UPLC-MS/MS Robert S. Plumb Waters Corporation Abstract Proteolysis targeting chimeras are bifunctional molecules with two molecular entities connected by…
