High Sensitivity SISCAPA-based Peptide Quantitation Using UHPLC and the 6490 QQQ with iFunnel Technology

The Agilent 6495 Triple Quadrupole LC/MS: Peptide Quantitation Performance Technical Overview Introduction Sample complexity and the low concentration of certain biomarkers are the major challenges encountered when performing biomarker verification using multiple reaction monitoring (MRM)-based methods. For this reason, the…

Automated, High Precision Tryptic Digestion and SISCAPA-MS Quantification of Human Plasma Proteins Using the Agilent Bravo Automated Liquid Handling Platform Application Note Authors Abstract Morteza Razavi, N. Leigh Anderson, An “addition only” tryptic protein-digestion protocol, followed by multiplexed Matthew E.…

Jet Stream Proteomics for Sensitive and Robust Standard Flow LC/MS Technical Overview Authors Introduction Yanan Yang, Vadiraj Bhat, and Proteomics research has typically used nanospray LC/MS to achieve maximum sensitivity when the sample amount is limited. Nanoflow LC/MS takes advantage…

Improving the Detection of Thyroglobulin in Human Plasma for Clinical Research by Combining SISCAPA Enrichment and Microflow LC-MS Jay S. Johnson,1 Morteza Razavi,2 James Murphy,1 Selena Larkin,2 and Paul Rainville1 1 Waters Corporation, Milford, MA, USA; 2 SISCAPA Assay Technologies,…