Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology

DEVELOPMENT OF A BIOANALYTICAL SPE LC-MS/MS ASSAY FOR OLIGONUCLEOTIDES Mary Lame, Kathryn Brennan, Michael Donegan, Thanai Paxton, and Ian Edwards Waters Corporation, 34 Maple Street, Milford, MA , USA INTRODUCTION RESULTS Over the past decade, there has been a dramatic…

Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High Performance Tandem Quadrupole Mass Spectrometer Suma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MA Introduction Results Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes has been of…

[ APPLICATION NOTEBOOK ] Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape Small Molecules Oligonucleotide Protein/Peptide Therapeutics Software Tools Targeted Imaging LC-MS/MS Solutions to Support Reliable, Sensitive and Efficient Workflows for the Bioanalysis of Drug Modalities Welcome to the Waters…

Application Note LC-MS Bioanalytical Quantification of a GalNAc-siRNA Conjugate Oligonucleotide Using Semi-Automated Solid Phase Extraction Mary Trudeau, Kathryn Brennan Waters Corporation Abstract The following work demonstrates the capabilities of the Pipette+ in combination with the Otto SPEcialist for semi-automated liquid…