LC-MS Bioanalytical Quantification of a GalNAc-siRNA Conjugate Oligonucleotide Using Semi-Automated Solid Phase Extraction

[ APPLICATION NOTEBOOK ] Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape Small Molecules Oligonucleotide Protein/Peptide Therapeutics Software Tools Targeted Imaging LC-MS/MS Solutions to Support Reliable, Sensitive and Efficient Workflows for the Bioanalysis of Drug Modalities Welcome to the Waters…

OLIGONUCLEOTIDE SAMPLE PREP & QUANTITATION: IMPROVED SPE PERFORMANCE USING A NOVEL SEMIAUTOMATED EXTRACTION MANIFOLD Mary Trudeau, Kathryn Brennan , Arjan Timmerman Waters Corporation, 34 Maple Street, Milford, MA , USA INTRODUCTION Solid phase extraction (SPE) is a common technique for…

M0930-10-64 Quantification of Oligonucleotide Therapeutics in Plasma Using a Generic Kit-Based Approach Margot Lee and Mary Trudeau Waters Corporation, Milford, MA USA CONTACT INFORMATION: [email protected] [email protected] RESULT(S) PURPOSE Developing LC-MS oligonucleotide bioanalytical sample preparation workflows are complex and laborious with…

[ CONSUMABLES GUIDE BOOK ] Quantifying Oligonucleotides Sample Extraction and LC Tools for Reliable LC-MS Quantitation of Oligonucleotides A Changing Industry There has been a resurgence in synthetic oligonucleotide therapeutics in the past decade, as seen with burgeoning pipelines across…