<p><strong>What if you could assess a tumor's metastatic potential — without extensive sample prep — directly from tissue? Rachel Wood is working on exactly that.</strong></p><p><strong>Rachel Wood</strong> is a PhD candidate at Queen's University (Kingston, Ontario),&nbsp;working jointly in the labs of Dr. Richard Oleschuk (Chemistry) and Dr. Chris&nbsp;Nicoll (Pathology &amp; Molecular Medicine). Her research applies Ambient Ionization Mass Spectrometry — specifically the Liquid Microjunction Surface Sampling Probe &nbsp;(LMJ-SSP) and Desorption Electrospray Ionization (DESI) — to profile the metabolomics of non-metastatic and metastatic clear cell Renal Cell Carcinoma (ccRCC) cell lines. The long-term goal: a rapid, minimally invasive MS-based prognostic tool for kidney cancer.</p><p>This is the first reported use of LMJ-SSP to assess metastatic status in ccRCC —&nbsp;and early PCA results are already showing distinct separation between cell line&nbsp;<br>profiles.</p><h5><strong>In this episode, David and Rachel cover:</strong></h5><ul><li>Why <strong>ccRCC</strong> is such a resistant biomarker problem despite active genomic, proteomic, and metabolomic research</li><li>The clinical stakes of "<strong>diagnosed by accident</strong>" — and what a prognostic biomarker actually needs to do for a clinician</li><li>How AIMS complements (not replaces) LC-MS in a discovery-phase cancer workflow</li><li><strong>LMJ-SSP vs. DESI</strong>: what each technique sees that the other misses, including spatial resolution differences (~1mm vs. ~50µm)</li><li>Why Rachel runs LMJ-SSP on both a triple quad and a Q-TOF — and what each instrument contributes to the same research question</li><li>How her lab repurposed a 3D printer as a custom automated XYZ sampling stage with 50µm movement precision</li><li>Managing high-dimensional metabolomics data across two polarities, two cell lines, and two mass analyzers — the pipeline explained</li><li>What unsupervised machine learning (PCA) showed in early results</li><li>The path from cell lines to excised tumor tissue to, ultimately, liquid biopsies</li><li>Advice for analytical chemists considering work at the chemistry–oncology interface</li></ul><h3><strong>Video Transcription</strong></h3><p><strong>Kidney cancer remains a difficult biomarker problem, particularly when researchers try to distinguish tumors that are likely to behave aggressively from those that are not. In a recent episode of </strong><i><strong>Concentrating on Chromatography</strong></i><strong>, PhD researcher Rachel Wood discussed how she is combining rapid ambient ionization mass spectrometry, LMJ-SSP, DESI, multivariate data analysis, and conventional LC-MS workflows to investigate the molecular differences associated with clear cell renal cell carcinoma and its metastatic potential.</strong></p><h4><strong>Returning to the research question that started it all</strong></h4><p>Wood first encountered kidney cancer research during her undergraduate studies. Although she later moved into a more instrumentation-focused master’s project involving breast cancer, the subject of kidney cancer remained unfinished business.</p><p>When the opportunity arose to choose a PhD project, she returned to the field that had originally sparked her interest in research. She is now conducting her doctoral work at <strong>Queen’s University in Kingston, Ontario</strong>, in an interdisciplinary environment spanning chemistry, pathology, molecular medicine, computer science, and clinical research.</p><h4><strong>Why clear cell renal cell carcinoma is such a difficult biomarker problem</strong></h4><p>Wood’s research focuses on <strong>clear cell renal cell carcinoma (ccRCC)</strong>, which represents the majority of kidney cancer cases discussed in the interview.</p><p>The difficulty is not a lack of research effort. Genomics, proteomics, and metabolomics studies have all produced promising biomarker candidates. The challenge is that different studies often identify different sets of markers, with relatively little overlap between them.</p><p>Patient-to-patient biological variability further complicates the picture. A candidate biomarker panel that performs well in one cohort may not reproduce equally well in another. Selecting which features deserve further investigation therefore becomes a major analytical and biological challenge.</p><h4><strong>From incidental diagnosis to prognostic information</strong></h4><p>Another difficulty is the way kidney cancer is often discovered.</p><p>Rather than being detected through a dedicated screening program, tumors may be found incidentally during imaging performed for another reason. According to Wood, the ideal solution would be a diagnostic biomarker capable of detecting kidney cancer early. Such a marker is not currently available within the scope of the work she described.</p><p>That places additional importance on <strong>prognostic biomarkers</strong>. Once a tumor has been detected, clinicians need as much information as possible about how aggressive it may be and how likely it is to progress.</p><p>Wood’s current work is therefore not attempting to declare directly that a particular patient has metastatic disease. Instead, the goal is to understand <strong>what changes biologically as a tumor moves from a less aggressive to a more aggressive state</strong>.</p><p>That means asking which molecular pathways change, which mechanisms become altered, and which analytes may eventually provide useful indicators of tumor behavior.</p><h4><strong>AIMS and LC-MS answer different questions</strong></h4><p>A central theme of the interview was the relationship between rapid ambient ionization mass spectrometry and conventional LC-MS.</p><p>Wood is clear that <strong>AIMS is not intended to replace LC-MS</strong>. Instead, she sees the two approaches as complementary.</p><p>AIMS provides a rapid way to obtain a broad molecular overview of a sample with minimal preparation. This makes it especially useful during the discovery phase, when the goal is to gather as much molecular information as possible and identify features that distinguish biological groups.</p><p>LC-MS then becomes valuable when those features need to be separated, characterized more carefully, and quantified with greater confidence.</p><p>In Wood’s workflow, rapid MS screening can therefore help identify which analytes deserve closer attention before more targeted LC-MS investigations are performed.</p><h4><strong>What “minimal sample preparation” actually means</strong></h4><p>The amount of sample preparation required depends strongly on the type of material being analyzed.</p><p>Wood currently works mainly with <strong>cultured human cell lines</strong>, which means much of the preparation begins with growing the cells themselves. Depending on the experiment, the cells may then be chemically lysed or subjected to fixation, paraffin embedding, and sectioning before analysis by <strong>LMJ-SSP</strong> or <strong>DESI</strong>.</p><p>She also notes that the possibilities would be different for freshly excised tumor material. In an appropriate perioperative or biosafety laboratory setting, LMJ-SSP could potentially be used to analyze tumor margins more directly.</p><p>The practical meaning of “minimal preparation” is therefore highly dependent on the sample and the analytical question being asked.</p><h4><strong>Why combine LMJ-SSP and DESI?</strong></h4><p>Rather than choosing between LMJ-SSP and DESI, Wood uses the two approaches because they provide different types of information.</p><p><strong>LMJ-SSP</strong> offers rapid, localized analysis and can accommodate samples with uneven surface topography, which is particularly useful for excised tissue.</p><p><strong>DESI</strong>, by contrast, provides substantially higher spatial resolution. In the workflow described in the interview, DESI can achieve spatial resolution on the order of tens of micrometers, whereas LMJ-SSP operates at a much larger sampling scale depending on probe design.</p><p>That higher spatial resolution is important when moving from simplified cell-line models toward actual tumor tissue, where the molecular organization of different regions may reveal biologically relevant differences.</p><p>Combining both techniques therefore enables researchers to balance speed, surface compatibility, and spatial information.</p><h4><strong>Two mass analyzers for two parts of the same problem</strong></h4><p>Wood also uses two different mass spectrometers in her LMJ-SSP work.</p><p>Most of the discovery work is carried out using a <strong>triple quadrupole mass spectrometer</strong>, particularly because her project focuses strongly on lower-mass analytes and small molecules.</p><p>Once statistically important analytes have been identified, a <strong>Q-TOF</strong> instrument can be used for MS/MS experiments and tentative structural identification.</p><p>The two instruments therefore address different stages of the workflow: one supports broad discovery and comparison, while the other provides additional structural information needed to connect selected features with possible metabolic pathways.</p><h4><strong>Turning a 3D printer into an automated sampling platform</strong></h4><p>One of the most unusual elements of the project is the automated sampling system used with LMJ-SSP.</p><p>Historically, LMJ-SSP measurements could be performed manually or with custom-built XYZ positioning stages. Wood’s laboratory instead adapted a <strong>3D printer</strong> into an automated positioning system.</p><p>Custom software controls the printer and moves the sampling probe with precise control over its X, Y, and Z positions. According to Wood, the system enables movements down to approximately <strong>50 µm</strong> and also controls parameters such as the contact time between the probe and sample and the delay between consecutive sampling events.</p><p>This level of automation improves reproducibility because variables that would otherwise depend on manual operation can be controlled systematically.</p><p>Even the Z-position can be programmed, allowing the probe to operate at constant or varying heights depending on the sample surface.</p><h4><strong>Managing high-dimensional MS data</strong></h4><p>The experimental design creates a large data-analysis challenge.</p><p>Wood is working with multiple cell lines, both ionization polarities, and more than one mass analyzer. To maintain traceability, she analyzes the data in clearly defined subsets.</p><p>A typical workflow might begin with one mass analyzer and one polarity. Within that condition, the lower-aggressiveness and higher-aggressiveness cell models can then be compared directly.</p><p>The data processing pipeline includes steps such as:</p><ul><li>binning,</li><li>normalization,</li><li>transformation,</li><li>dimensionality reduction,</li><li>identification of discriminating molecular features.</li></ul><p>Once relevant features are identified, MS/MS analysis can be used to investigate them further. The same process is then repeated across other polarities and instruments.</p><h4><strong>Unsupervised machine learning reveals distinct molecular profiles</strong></h4><p>Machine learning is particularly valuable because the AIMS datasets are highly dimensional, containing very large numbers of molecular features across multiple samples.</p><p>Wood’s initial analysis has included <strong>principal component analysis (PCA)</strong>, an unsupervised dimensionality-reduction technique.</p><p>The early results are encouraging: the non-metastatic and metastatic cell-line models separate clearly in PCA space.</p><p>That does not itself identify a definitive biomarker panel, but it indicates that the two biological states have distinguishable molecular profiles even though both belong to the same kidney cancer subtype.</p><p>This provides an important foundation for identifying which specific metabolites or molecular pathways may be responsible for the separation.</p><h4><strong>Testing LMJ-SSP for metastatic status</strong></h4><p>A particularly novel aspect of Wood’s project is the use of LMJ-SSP to investigate differences associated with metastatic status.</p><p>She had previously worked on distinguishing healthy and cancerous tissues, where the biological differences are relatively large. Comparing two states within the same cancer type is more demanding because the molecular changes may be much subtler.</p><p>The scientific motivation, however, is strong. Tumors discovered at later stages carry greater concern for metastatic progression, making it important to understand the molecular changes associated with increasingly aggressive behavior.</p><p>For Wood, this made the methodological risk worthwhile: the analytical challenge directly addresses an area where better prognostic information could ultimately have clinical value.</p><h4><strong>A long-term goal: rapid MS-based prognostic testing</strong></h4><p>The long-term vision extends beyond cell-line research.</p><p>Wood is interested in whether rapid, minimally invasive mass spectrometry could eventually contribute to clinical decision-making.</p><p>One possibility would be identifying a diagnostic biomarker in a <strong>liquid biopsy</strong>, potentially using blood or urine. A urine-based marker capable of contributing to earlier detection would be particularly attractive for kidney cancer.</p><p>For prognostic applications, the goal would be slightly different. Once a tumor is discovered, molecular information could help characterize its likely behavior and provide clinicians with additional evidence when deciding between immediate treatment, surgery, or other management strategies.</p><p>Wood emphasizes that such a tool would not replace standard clinical workflows. Instead, it would provide additional molecular information to complement existing diagnostic and pathological approaches.</p><h4><strong>Why interdisciplinary work matters</strong></h4><p>Throughout the interview, Wood repeatedly returns to the importance of collaboration.</p><p>Her research sits at the intersection of analytical chemistry, pathology, oncology, computation, and clinical medicine. No single researcher can remain equally current in all of these fields.</p><p>Working closely with pathologists, computer scientists, surgeons, medical students, and other specialists therefore provides both scientific expertise and a way to stay connected with developments outside one’s immediate discipline.</p><p>For Wood, the biological context has also changed how she thinks about analytical chemistry. Developing a new instrument or method is important, but understanding <strong>who may ultimately benefit from that analytical capability</strong> makes the research more meaningful.</p><p>That patient-centered perspective is now an integral part of how she approaches the project.</p><h4><strong>An intersection full of opportunities</strong></h4><p>Wood describes the interface between analytical chemistry and oncology as an especially exciting area for young researchers.</p><p>The work can range from troubleshooting instrumentation to interpreting pathology, developing statistical methods, and collaborating across disciplines. That diversity creates constant opportunities to learn and to apply analytical chemistry to clinically relevant questions.</p><p>Her project illustrates that modern mass spectrometry research is increasingly about more than generating spectra. It involves connecting instrumentation, spatial sampling, multivariate statistics, machine learning, biological interpretation, and clinical needs into a single analytical strategy.</p><p>And in kidney cancer, where reliable prognostic biomarkers remain difficult to establish, that integrated approach may be particularly valuable.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

AIMS vs. LC-MS for Cancer Diagnostics: ccRCC Metabolomics with Rachel Wood

<p><strong>In the week of September 21, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>6 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Waters Corporation: Strengthening SPE Workflows for Today’s Laboratory</strong></h5><ul><li>Mo, 21.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6514">Registration</a></li></ul><p>Learn how to optimize SPE workflows with best practices for sorbent selection, recovery troubleshooting, and reducing matrix effects in modern analytical laboratories.</p><h5><strong>2. Agilent Technologies: From Crude to Candidate: Scaling Preparative Chromatography with Confidence</strong></h5><ul><li>Mo, 21.9.2026 18:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6498">Registration</a></li></ul><p>Learn how to scale preparative chromatography from crude sample to purified candidate, with practical strategies for method development, fraction collection, and method transfer.</p><h5><strong>3. SCIEX: Extending the power of LC MS/MS: advanced workflows with QTRAP®</strong></h5><ul><li>Tu, 22.9.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6518">Registration</a></li></ul><p>Discover how MRM³ and QTRAP workflows provide greater selectivity and lower limits of quantification for LC-MS/MS analysis in complex matrices.</p><h5><strong>4. Technology Networks: Improving Efficiency in Routine PFAS Analysis Using EPA Methods 533 and 1633A</strong></h5><ul><li>Tu, 22.9.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6517">Registration</a></li></ul><p>Explore how automated QC monitoring and the SCIEX novus V55 system support high-throughput PFAS quantitation using EPA Methods 533 and 1633A.</p><h5><strong>5. Phenomenex: Expanding the Evidence: New Data for More Reliable PFAS Analysis</strong></h5><ul><li>We, 23.9.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6522">Registration</a></li></ul><p>Discover how new analytical data and contamination control strategies can improve baseline performance, sensitivity, and reliability in PFAS analysis.</p><h5><strong>6. SCIEX: How is capillary electrophoresis being used to analyze DNA and RNA</strong></h5><ul><li>We, 23.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6521">Registration</a></li></ul><p>Explore how capillary electrophoresis supports DNA and RNA analysis, from plasmid quality assessment to mRNA impurity profiling, viral vector characterization, and oligonucleotide workflows.</p><h5><strong>7. Thermo Fisher Scientific: A novel monodisperse supermacroporous reversed-phase platform for comprehensive nucleic acid analysis across a broad size range</strong></h5><ul><li>We, 23.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6476">Registration</a></li></ul><p>Discover how a novel monodisperse supermacroporous reversed-phase platform enables comprehensive nucleic acid analysis across a broad size range, from short oligonucleotides to mRNA.</p><h5><strong>8. Waters Corporation: The Next Frontier in Nitrosamines Testing: Detection and Risk Assessment in Packaging and IV Infusion Bags</strong></h5><ul><li>We, 23.9.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6520">Registration</a></li></ul><p>Learn how LC-MS/MS supports nitrosamine detection and risk assessment in packaging materials while addressing extractables and leachables challenges in IV infusion bags.</p><h5><strong>9. MDPI: Membrane Technologies for Water and Food Sustainability</strong></h5><ul><li>We, 23.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6561">Registration</a></li></ul><p>Explore membrane technologies for water and food sustainability, international research collaboration, and opportunities within the CYTED Program.</p><h5><strong>10. Agilent Technologies: Unlocking Lab Productivity: Automation Opportunities for LC/MS Laboratories</strong></h5><ul><li>We, 23.9.2026 18:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6495">Registration</a></li></ul><p>Discover how automation can increase productivity in LC/MS laboratories by reducing manual tasks, improving workflow efficiency, and supporting scalable analytical operations.</p><h5><strong>11. Thermo Fisher Scientific: Comparison of biocompatible and inert UHPLC systems for LC-UV quantitation of large RNA</strong></h5><ul><li>Th, 24.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6477">Registration</a></li></ul><p>Learn how the Vanquish Amplify system minimizes metal interactions during LC-UV analysis of large RNA and explore the performance of biocompatible and inert UHPLC systems.</p><h5><strong>12. Agilent Technologies: Next-Generation Pathogen Genomics: The Long-Read Advantage</strong></h5><ul><li>Th, 24.9.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6526">Registration</a></li></ul><p>Explore long-read sequencing and automated target enrichment in pathogen genomics and learn how Agilent SureSelect and Magnis NGS support improved pathogen detection.</p><h5><strong>13. Evosep Biosystems: Advancing Plasma Proteomics</strong></h5><ul><li>Th, 24.9.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6523">Registration</a></li></ul><p>Discover advances in plasma proteomics and learn how high-throughput analytical workflows can accelerate biomarker discovery and cancer research.</p><h5><strong>14. Waters Corporation: Applications of Multi-Angle Light Scattering for Biotherapeutic Characterization</strong></h5><ul><li>Th, 24.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6430">Registration</a></li></ul><p>Learn how multi-angle light scattering (MALS) supports confident characterization of monoclonal antibodies, antibody-drug conjugates, and AAV viral vectors.</p>

Webinars LabRulezLCMS Week 39/2026

Forced degradation analysis of recombinant adeno-associated virus serotype 8 based on analytical anion exchange chromatography coupled to orthogonal characterization

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Waters CERTIFIED HPLC Vials

Reducing failed assays from unknown contaminant peaks and limiting instrument downtime from out of specification vials is a priority for your lab. Waters sample vials can help you do just that.

<div><div><h4><strong>Meet your analytical challenges with the right vial.</strong></h4></div></div><div><div><p><strong>The right vial.&nbsp;</strong><span><strong>A world of difference.</strong></span></p><p>Reducing failed assays from unknown contaminant peaks and limiting instrument downtime from out of specification vials is a priority for your lab. Waters sample vials can help you do just that.</p><p>All Waters sample vials are held to the tightest dimensional tolerances. Manufactured via a 2-, 3-, or 4-step certification process, we ensure that Waters Certified Vials meet and maintain specified vial dimensions, levels of cleanliness and adsorption properties from batch to batch.&nbsp;Find the right vial for your application and autosampler - use our <a target="_blank" rel="noopener noreferrer" href="https://find.waters.com/VialSelector/"><strong>Vial Selector</strong></a> to find your perfect match.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_118649175c.jpg" alt="Waters CERTIFIED Vials: Table 1. Vials for Routine and Advanced Analyses." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_118649175c.jpg 245w," sizes="100vw" width="1226" height="754"></p><h3><strong>Waters LCMS CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><p><span><strong>✅ </strong></span>MS Scan</p><ul><li>Low MS interferences from known residues &amp; polymers</li><li>For routine QC and LC-MS analysis with lower analyte concentrations from 10-100s ng/ml.</li></ul><h3><strong>Waters TruView<sup>TM</sup> LCMS CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><p><span><strong>✅ </strong></span>MS Scan</p><p><span><strong>✅&nbsp;</strong></span>Low Adsorption Test</p><div><div><ul><li>Lowest MS interferences from known residues &amp; polymers</li><li>For high-end LC-MS analysis and quantification of analytes with a concentration of below 1 ng/ml with reduced adsorption of polar analytes.</li></ul><h3><strong>Waters CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><div><div><ul><li>No UV interferences caused caused by manufacturing and packaging residues</li><li>For routine QC LC-UV analysis&nbsp;of compounds in µg/mL&nbsp;concentrations.&nbsp;</li></ul><h3><strong>MAXPEAK QuanRecovery</strong></h3><ul><li>For high recovery peptide and protein quantification workflows. Reduces sample losses due to non-specific binding (NSB) and ionic interactions.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_2_4fba532335.jpg" alt="Waters CERTIFIED Vials: Vials Shapes." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_2_4fba532335.jpg 245w," sizes="100vw" width="1261" height="617"></p><div><div><h3><strong>Control data quality risks and reduce unexpected or ghost peaks</strong></h3><p>Don’t let the presence of background noise impact your results, causing data quality risks and unexpected or ghost peaks. Background noise can come from many factors.&nbsp;One of the most important factors are vial and septa cleanliness, which introduces contamination peaks. Ghost peaks are introduced by analyte degradation that can be triggered by significant pH changes in the diluent. In this chromatogram, the top shows normal behavior, and the bottom chromatogram shows ghost peaks.</p><p>Waters Certified vials are cleanliness tested so you don’t have to worry about contaminant peaks. The TruView pH Control Vials are certified to minimize and control a pH shift away from the neutral.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_4_7749301ba1.jpg" alt="Waters CERTIFIED Vials: Prevent the appearance of unexpected peaks during LC/UV analysis with Waters LC/GC Certified Vials as a control strategy." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_4_7749301ba1.jpg 245w," sizes="100vw" width="1024" height="535"></p><h3><strong>More time on development. Less on troubleshooting</strong></h3><p>Stop losing valuable development time on troubleshooting due to analyte loss from non-specific adsorption. Waters TruView pH Control LCMS Certified Vials have the lowest adsorptive losses on the market, and you can rely on them to provide consistency from batch to batch and vial to vial. This chromatogram shows a comparison of adsorptive loss of chlorhexidine in a variety of vials.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_5_d3e42fa7f2.jpg" alt="Waters CERTIFIED Vials: Comparison of adsorptive loss of chlorhexidine acetate in a variety of vials." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_5_d3e42fa7f2.jpg 245w," sizes="100vw" width="1024" height="633"></p><div><div><h3><strong>Ideal for demanding MS work</strong></h3><p>LCMS Certified Vials are suited for analyte concentrations in the 100s ng/mL concentration. Waters LCMS Certified Vials are tested by MS scans from 250 to 1000 <i>m/z</i> with specifications set on the total ion count and presence of clusters in the high mass range. This chromatogram shows a comparison of typical MS scans of Waters LCMS Certified Vials to vials of other sources and clean solvents.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_3_4869fbf57a.jpg" alt="Waters CERTIFIED Vials: Comparing typical MS scans of Waters LCMS Certified Vials, with vials from other sources." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_3_4869fbf57a.jpg 245w," sizes="100vw" width="1024" height="406"></p><div><div><h3><strong>Stay in control of your samples' pH</strong></h3><p>The analysis of low abundance species, pH sensitive analytes or not yet well understood compound mixtures benefit from consistent and well controlled vial surfaces. The glass surface of TruView pH Control LCMS Certified Vials minimizes pH shifts away from the neutral and thus eliminates unwanted reactions and resulting ghost peaks.&nbsp;Ghost peaks are very difficult to troubleshoot.</p><p>Waters TruView pH Control LCMS Certified vials were used to analyze two compounds, drospirenone and lovastatin. The TruView pH Control LCMS Certified Vials show little to no degradant formed over the time tested. Standard glass vials showed considerable degradant formation over the same testing time with irreproducible formation of the degradant across different vials.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_6_4dc330d849.jpg" alt="Waters CERTIFIED Vials: UV peak areas of lovastatin degradant across replicate vials and different vial types. Error bars indicate standard deviation for the replicate injection peak area." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_6_4dc330d849.jpg 245w," sizes="100vw" width="1024" height="605"></p><div><div><h3><strong>Reducing adsorption starts here</strong></h3><p>Inconsistent analytical results from small molecule analyte adsorption onto the surface of glass vials can be a problem at today’s low analyte concentrations. Some scientists have even experienced total analyte loss with samples stored in vials for an extended time. The vial chemistry, specifically the&nbsp;glass surface, is the major contributor to this problem.</p><p>Polar analytes&nbsp;may adsorb to the glass vial surface by polar-polar interaction and/or ion exchange mechanisms, thereby reducing the overall amount of sample in solution. TruView Certified LCMS Vials&nbsp;reduce this problem dramatically due to a stringent manufacturing process. The process yields a glass surface that has a lower concentration of free ions on the surface.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_8_064003b933.jpg" alt="Waters CERTIFIED Vials: Nortriptyline at 1 ppb concentration in several vials. The tall peak is the initial injection; the smaller peak (overlaid) is the four-hour injection. The first two chromatograms are competitor’s vials. The third chromatogram is for the Waters TruView LCMS Certified vial. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_8_064003b933.jpg 245w," sizes="100vw" width="1912" height="1182"></p><div><div><h3><strong>No analyte left behind</strong></h3><p>Instrument development is yielding more sensitive mass spectrometers. With more sensitive instruments, analytes can be detected at pg/mL levels. At these concentrations, understanding adsorption issues is critical for good quantitative results. We tested adsorption loss for the major manufacturers and saw high sample loss across manufacturers and clear and amber glass types – with significantly less loss with Waters TruView Autosampler Vials.</p><h4><strong>Average Analyte Loss</strong></h4><p><strong>Manufacturer: Clear Glass / Amber Glass</strong></p><ul><li><strong>Vendor A</strong>: 55% / 69%</li><li><strong>Vendor B</strong>: 25% / 25%</li><li><strong>Vendor C</strong>: 54% / 74%</li><li><strong>Vendor D</strong>: 18% / 59%</li><li><strong>Vendor E</strong>: 75% / Not tested</li><li><strong>Waters TruView LCMS Certified Vial</strong>: 1% / 6%</li></ul></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Waters SARS-CoV-2 LC-MS Kit (RUO)

Advance virus research with Waters' RUO LC-MS kit for SARS-CoV-2. Detect and quantify NCAP peptides with high sensitivity and reproducibility using SISCAPA antibody enrichment and automation-ready workflows.

<h4><strong>Detect and quantify SARS-CoV-2 NCAP peptides to advance virus research</strong></h4><p>The global <strong>COVID-19 pandemic</strong> created an unprecedented need to quickly deploy emergency tests for SARS-CoV-2 infection. Now, scientists can harness the flexibility and reproducibility of LC-MS to advance critical SARS-CoV-2 research.</p><p><strong>Waters SARS-CoV-2 LC-MS Kit (RUO)</strong> is a <strong>Research Use Only kit</strong> to directly <strong>detect and quantify SARS-CoV-2</strong> signature nucleocapsid peptides (NCAPs) without the need to amplify the target analytes – so you can ensure accuracy, reproducibility, and sensitivity for your most critical research.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SARS_Co_V_2_LC_MS_Kit_RUO_2_50b4ae9b00/Waters-SARS-CoV-2-LC-MS-Kit-(RUO)-2.jpg" alt="Waters: SARS-CoV-2 LC-MS Kit (RUO)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SARS_Co_V_2_LC_MS_Kit_RUO_2_50b4ae9b00/thumbnail_Waters-SARS-CoV-2-LC-MS-Kit-(RUO)-2.jpg 234w," sizes="100vw" width="660" height="440"></p><h4><strong>Overview</strong></h4><ul><li>Achieve <strong>reproducible results</strong> between and within labs &nbsp;</li><li>Ensure <strong>high accuracy</strong> and analytical <strong>sensitivity</strong> to enable critical research &nbsp;</li><li><strong>Empower research</strong> and development of pioneering SARS-CoV-2 testing with an alternative and complementary technology to common infectious pathogen research &nbsp;</li><li>Enable <strong>broader research with an LC-MS method </strong>with the potential to be multiplexed with other peptides and biomarkers&nbsp;</li></ul><p><i><strong>* </strong>This kit is for research use only and has not been approved for use in clinical diagnostic procedures. This RUO kit has not been tested with clinical samples. The SARS-CoV-2 kit for SARS-CoV-2 nucleocapsid peptides is not available in all countries, please contact your Waters representative for more details.</i></p><p><strong>Recommended Use:</strong> For the detection and quantification of SARS-CoV-2 signature NCAP peptides.</p><h4><strong>LC-MS enables cutting-edge SARS-CoV-2 research</strong></h4><p>The Waters SARS-CoV-2 LC-MS Kit (RUO) is a Research Use Only kit intended for the quantitative measurement of three proteolytic peptides derived from the SARS-CoV-2 Nucleocapsid (NCAP) protein. The method has been optimized on an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/199"><strong>ACQUITY UPLC I-Class PLUS</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/195"><strong>Xevo TQ-XS System</strong></a> and is also intended for use with the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/208"><strong>Andrew+ Pipetting Robot</strong></a>. Optimization on other instrument platforms is possible. &nbsp;</p><p>Further investigation is needed to collect objective evidence in promising research applications, however, based on the properties of the analytical test method, the SARS-CoV-2 LC-MS Kit might be leveraged for the following research studies: &nbsp;</p><ul><li>Peptide concentration to quantitate SARS CoV-2 signature peptides at different stages of infection&nbsp;</li><li>Research of infection and long-term effects through peptide quantitation&nbsp;</li></ul><p>Future pandemic preparedness studies and research of signature peptide-based biomarkers unique to other infections </p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_SARS_Co_V_2_LC_MS_Kit_RUO_allows_for_easy_sample_preparation_sample_enrichment_and_sample_detection_f0aca034ad.jpg" alt="Waters: The SARS-CoV-2 LC-MS Kit (RUO) allows for easy sample preparation, sample enrichment, and sample detection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_SARS_Co_V_2_LC_MS_Kit_RUO_allows_for_easy_sample_preparation_sample_enrichment_and_sample_detection_f0aca034ad.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Achieve confidence in results</strong></h4><p>Ensure accurate and consistent results with highly analytically selective antibody magnetic bead enrichment. With the innovative SISCAPA® anti-peptide antibody enrichment sample preparation method from SISCAPA Assay Technologies, Inc. in the SARS-CoV-2 LC-MS Kit (RUO), you can improve the performance of mass spectrometry for measurement of pre-selected protein targets.</p><p>With the SARS-CoV-2 LC-MS Kit (RUO) and SISCAPA, you can achieve the analytical sensitivity you need to detect low levels of SARS-CoV-2 peptides from complex digested samples with stable isotope standards and capture by anti-peptide antibodies. Increase laboratory efficiency with all the components your busy research laboratory needs to quickly deploy the supplied method - all in one package.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_SARS_Co_V_2_method_minimizes_sample_media_interference_providing_greater_flexibility_for_the_analysis_of_multiple_research_samples_fe3a56c686.jpg" alt="Waters: The SARS-CoV-2 method minimizes sample media interference, providing greater flexibility for the analysis of multiple research samples." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_SARS_Co_V_2_method_minimizes_sample_media_interference_providing_greater_flexibility_for_the_analysis_of_multiple_research_samples_fe3a56c686.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Ensure reproducibility with trusted chemistries and consumables</strong></h4><p>Ensuring reproducible quantitation from sample-to-sample, run-to-run, and lab-to-lab provides the confidence you need for critical research decisions. Ensuring reproducibility starts with minimizing variability risks, including the risk of unpredictable non-specific binding of peptides to surfaces. The SARS-CoV-2 LC-MS Kit uses QuanRecovery Plates with MaxPeak HPS and a MaxPeak Premier Peptide Column, minimizing non-specific binding of peptides to surfaces while enhancing recovery and signal.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Analytical_sensitivity_of_the_ADE_AYN_and_NPA_peptides_in_VTM_at_2_3_5_10_and_20_amol_L_following_antibody_enrichment_145d5249ef.jpg" alt="Waters: Analytical sensitivity of the ADE, AYN, and NPA peptides in VTM at 2, 3, 5, 10, and 20 amolµL following antibody enrichment." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Analytical_sensitivity_of_the_ADE_AYN_and_NPA_peptides_in_VTM_at_2_3_5_10_and_20_amol_L_following_antibody_enrichment_145d5249ef.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Let Andrew+ pipette for you</strong></h4><p>Save valuable time and focus on your research with reliable and reproducible sample preparation using the Andrew+ Pipetting Robot. The SARS-CoV-2 LC-MS Kit (RUO) comes in an automation-friendly format with liquid handling protocols for the Andrew+ Pipetting Robot available on OneLab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SARS_Co_V_LC_MS_Kit_RUO_automation_protocol_available_for_Andrew_Pipetting_Robot_It_provides_a_flexible_automation_platform_easily_adaptable_to_multiple_workflows_8dca9a99e0.jpg" alt="Waters: SARS-CoV-LC-MS Kit (RUO) automation protocol available for Andrew + Pipetting Robot. It provides a flexible automation platform easily adaptable to multiple workflows." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SARS_Co_V_LC_MS_Kit_RUO_automation_protocol_available_for_Andrew_Pipetting_Robot_It_provides_a_flexible_automation_platform_easily_adaptable_to_multiple_workflows_8dca9a99e0.jpg 234w," sizes="100vw" width="1024" height="682"></p>

Watrex Deltasil 100 C18 HPLC columns

Need a high quality column at an affordable price? Deltasil™ columns are filled with standard reversed phase for a wide range of applications.

<p><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?s=watrex+deltasil+100+C18&amp;post_type=product&amp;dgwt_wcas=1?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex DeltaSil™ 100 C18</strong></a><strong> column is a standard reversed phase for wide field of applications in analysis</strong><br><strong>of drugs, organic compounds, peptides and others.</strong></p><p>Stationary phase is based on <strong>synthetic 5 μm silica-gel with 100 Å pores and 15% carbon content</strong>. The column has a good peak symmetry and efficiency.</p><p>Theoretical plate count value for non-polar compounds, such as naphthalene, reaches <strong>up to 90.000 theoretical plates per meter</strong>.</p><p>A <strong>wide range of column sizes</strong> is available, with additional dimensions available on request.</p><p>We are committed to the <strong>sustainability</strong> of our columns and therefore also offer <strong>backfill</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_Deltasil_HPLC_column_Mobile_phase_85_ACN_Flowrate_0_65_mlmin_Pressure_54_bar_Detection_254_nm_Injection_2_ml_de7068538f.jpg" alt="Watrex: Watrex Deltasil HPLC column (Mobile phase 85% ACN; Flowrate 0.65 mlmin; Pressure 54 bar; Detection 254 nm; Injection 2 μl)"></p><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>WI02DC181254</strong> Watrex Deltasil™ 100 C18, 5 μm, 125x4 mm column (<strong>Price 234 € ex VAT</strong>)</li><li><strong>WI02DC181504 </strong>Watrex Deltasil™ 100 C18, 5 μm, 150x4 mm column (<strong>Price 234 € ex VAT</strong>)</li><li><strong>WI02DC1815046</strong> Watrex Deltasil™ 100 C18, 5 μm, 150x4,6 mm column</li><li><strong>WI02DC182504</strong> Watrex Deltasil™ 100 C18, 5 μm, 250x4 mm column (<strong>Price 296 € ex VAT</strong>)</li><li><strong>WI02DC1825046</strong> Watrex Deltasil™ 100 C18, 5 μm, 250x4,6 mm column</li><li><strong>WI02DC182508</strong> Watrex Deltasil™ 100 C18, 5 μm, Semi-prep 250x8 mm column (<strong>Price 482 € ex VAT</strong>)</li></ul>

Watrex Polymer IEX HPLC columns

Do you need HPLC columns for the determination of organic acids, alcohols and sugars? Columns filled with a monodisperse sorbent based on sulfonated styrenedivinylbenzene.

<p><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?s=watrex+polymer+iex&amp;post_type=product&amp;dgwt_wcas=1?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex Polymer IEX™</strong></a><strong> is the Europe’s leading sorbent for ion exclusion analysis of alcohols, carboxylic acids, sugars, and polysacharides</strong></p><ul><li>H⁺, Ca²⁺, Pb²⁺ and Na⁺ forms</li><li>Unique monodispersed sorbent based on sulfonated polystyrene</li><li>Bulk packing materials available</li></ul><h3><strong>H form</strong></h3><p>The hydrogen form is suitable for <strong>organic acids</strong>, <strong>alcohols</strong> and <strong>some sugars</strong> in natural materials. The column is particularly suitable for the analysis of <strong>fruit drinks</strong>, <strong>wine</strong>, etc. Its great advantage is the high stability of retention times and the wide concentration range of analytes.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Column_250x8mm_IEX_H_4da682fa13.jpg" alt="Watrex: Column 250x8mm IEX H"></p><h3><strong>Ca form</strong></h3><p>The calcium form is characterized by good selectivity for the separation of <strong>mono-</strong> and <strong>disaccharides</strong> in natural materials. The column must be protected from anions forming insoluble calcium salts (phosphates, sulphates, etc.) and cations with a higher affinity for the sorbent than calcium ions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Column_250x8mm_IEX_Ca_b840dddcce.jpg" alt="Watrex: Column 250x8mm IEX Ca"></p><h3><strong>Pb form</strong></h3><p>The lead form is suitable for the separation of <strong>mono-</strong> and <strong>disaccharides</strong> in natural materials. The column must be protected from anions forming insoluble lead salts (phosphates, sulphates, etc.) and cations with a higher</p><p>Use the appropriate <strong>pre-column to extend the life</strong> of the analytical column.</p><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>WI020223</strong> Watrex 300x8 mm Polymer IEX H form, 8 um</li><li><strong>WI020213</strong> Watrex 300x8 mm Polymer IEX Ca form, 8 um</li><li><strong>WI020253</strong> Watrex 300x8 mm Polymer IEX Pb form, 8 um</li><li><strong>WI02022</strong> Watrex 250x8 mm Polymer IEX H form, 8 um (<strong>Price 926 € ex VAT</strong>)</li><li><strong>WI02021</strong> Watrex 250x8 mm Polymer IEX Ca form, 8 um (<strong>Price 926 € ex VAT</strong>)</li><li><strong>WI02025</strong> Watrex 250x8 mm Polymer IEX Pb form, 8 um (<strong>Price 926 € ex VAT</strong>)</li><li><strong>WI02122</strong> Guard column insert 10x4.0 mm PEEK Polymer IEX H 8 um, 10 pcs</li><li><strong>WI02121</strong> Guard column insert 10x4.0 mm PEEK Polymer IEX Ca 8 um, 10 pcs</li><li><strong>WI029012</strong> Guard column holder (for 10x4.0 mm PEEK insert)</li></ul>

Watrex IonPlus HPLC columns

Do you perform cation or anion analysis and need the right column at an affordable price? Our Watrex IonPlus™ columns are just what you are looking for!

<p>Watrex IonPlus™ are special columns for <strong>ion chromatography</strong>. The matrix used is <strong>styrene-divinylbenzene based</strong> and can withstand higher organic modifier content in the mobile phase.</p><h3><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/hplc-columns/watrex-columns/ion-exchange/watrex-ionplus-cs19-ic-column-250x46mm/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex IonPlus™ CS19</strong></a></h3><ul><li>Styrene-divinylbenzene, 55% cross-linking (7 μm particle i.d.)</li></ul><p>The Watrex IonPlus™ CS19 is an optimized column designed for the separation of <strong>common cations</strong>, small <strong>polar amines</strong> and moderately <strong>hydrophobic</strong> and <strong>polyvalent cations</strong> using simple aqueous eluents and elevated temperatures. They provide excellent separation of <strong>alkali metals</strong>, <strong>alkaline earth metals</strong>, <strong>alkylamines</strong>, <strong>alkanolamines</strong> and <strong>biogenic amines</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/HPLC_kolona_Watrex_Ion_Plus_CS_19_738c29ff57/HPLC-kolona-Watrex-IonPlus-CS19.png" alt="Watrex: Separation of anions in a Watrex IonPlus CS19 HPLC column"></p><h3><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/hplc-columns/watrex-columns/ion-exchange/watrex-ionplus-as19-ic-column-250x46mm/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex IonPlus™ AS19</strong></a></h3><ul><li>Styrene-divinylbenzene, 55% cross-linking (12 μm particle i.d.).</li></ul><p>Watrex IonPlus™ AS19 is a column analyzing common <strong>inorganic anions</strong> including <strong>fluorides</strong>, <strong>chlorites</strong>, <strong>bromates</strong>, <strong>chlorides</strong>, <strong>nitrates</strong>, <strong>phosphates</strong> and <strong>sulphates</strong> in drinking, underground and waste water or other matrices.</p><h3><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/hplc-columns/watrex-columns/ion-exchange/watrex-150x4mm-ic-anion-i-7um/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex IC Anion I</strong></a></h3><ul><li>Styrene-divinylbenzene (7 μm particle i.d.)</li></ul><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>WCS19250046</strong> Watrex IonPlus™ CS19 IC Column 250x4,6mm, 7 um (<strong>Price 1 169 € ex VAT</strong>)</li><li><strong>WCS19150030</strong> Watrex IonPlus™ CS19 IC Column 150x3mm, 7 um</li><li><strong>WCS19150040</strong> Watrex IonPlus™ CS19 IC Column 150x4mm, 7 um</li><li><strong>WCS19250030</strong> Watrex IonPlus™ CS19 IC Column 250x3mm, 7 um</li><li><strong>WAS19250046</strong> Watrex IonPlus™ AS19 IC Column 250x4,6mm, 7 um (<strong>Price 1 090 € ex VAT</strong>)</li><li><strong>WAS19150030</strong> Watrex IonPlus™ AS19 IC Column 150x3mm, 7 um</li><li><strong>WAS19150040</strong> Watrex IonPlus™ AS19 IC Column 150x4mm, 7 um</li><li><strong>WAS19250030</strong> Watrex IonPlus™ AS19 IC Column 250x3mm, 7 um</li><li><strong>WAS1925046</strong> Watrex IonPlus™ AS19 IC Column 250x4.6mm, 12 μm</li><li><strong>WI021540</strong> Watrex IC Anion I 150x4mm, 7 μm (<strong>Price 731 € ex VAT</strong>)</li><li><strong>CAT12546</strong> WATREX 125×4.6mm Universal Cat II, 7um (<strong>Price 584 € ex VAT</strong>)</li></ul>

Watrex DeltaGel GPC/SEC columns

Do you need a GPC column for SEC chromatography in organic solvents at an affordable price? Our Watrex Deltagel™ are just what you are looking for!

<p><strong>Watrex DeltaGel™</strong> are special mixed-bed GPC columns for <strong>SEC chromatography</strong> in organic solvents.</p><p>The columns are based on <strong>polystyrene</strong> and are intended especially for <strong>separation of synthetic polymers</strong> in organic solvents.</p><p>We offer <strong>4 variants of columns</strong> that differ in their separation range.</p><p>Columns are available in various sizes for both <strong>analytical</strong> and <strong>preparative</strong> applications.</p><h3><strong>Linear range:</strong></h3><ul><li><strong>DeltaGel Mixed-E</strong> (0 - 33 000 Da)</li><li><strong>DeltaGel Mixed-D</strong> (1 000 - 200 000 Da)</li><li><strong>DeltaGel Mixed-C</strong> (5 000 - 500 000 Da)</li><li><strong>DeltaGel Mixed-B</strong> (20 000 - 7 000 000)</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Delta_Gel_GPC_SEC_kolony_7dfd459a06/Watrex-DeltaGel-GPC-SEC-kolony.jpg" alt="Watrex: DeltaGel GPC SEC columns for the separation of synthetic polymers"></p><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>DGB.25020</strong> Watrex 250x20 mm DeltaGel™ Mixed-B, 5 um</li><li><strong>DGC.25020</strong> Watrex 250x20 mm DeltaGel™ Mixed-C, 5 um</li><li><strong>DGD.25020</strong> Watrex 250x20 mm DeltaGel™ Mixed-D, 5 um</li><li><strong>DGE.25020</strong> Watrex 250x20 mm DeltaGel™ Mixed-E, 5 um</li><li><strong>DGB.3008</strong> Watrex 300x8 mm DeltaGel™ Mixed-B, 5 um (<strong>Price 1 269 € ex VAT</strong>)</li><li><strong>DGC.3008</strong> Watrex 300x8 mm DeltaGel™ Mixed-C, 5 um (<strong>Price 1 269 € ex VAT</strong>)</li><li><strong>DGD.3008</strong> Watrex 300x8 mm DeltaGel™ Mixed-D, 5 um (<strong>Price 1 269 € ex VAT</strong>)</li><li><strong>DGE.3008</strong> Watrex 300x8 mm DeltaGel™ Mixed-E, 5 um (<strong>Price 1 269 € ex VAT</strong>)</li><li><strong>DGB.25020G</strong> WATREX 30x20 mm DeltaGel™ Mixed-B, 5um, Guard Column</li><li><strong>D2K4101927</strong> Derivatizating agents AQC 5x3 mg</li><li><strong>DGB.0508 </strong>WATREX 50×8mm DeltaGel 5 um, Guard column (<strong>Price 390 € ex VAT</strong>)</li></ul>

Thermo Scientific QuEChERS Sample Preparation Kits

QuEChERS is a versatile sample preparation method for analyzing pesticides, veterinary drugs, and other residues in various sample types before GC-MS or LC-MS analysis.

<div><div><div><h3><strong>QuEChERS sample preparation—now easier, more convenient, and affordable</strong></h3><p><strong>QuEChERS</strong> (<strong><u>Q</u></strong><u>u</u>ick, <strong><u>E</u></strong>asy, <strong><u>C</u></strong>heap, <strong><u>E</u></strong>ffective, <strong><u>R</u></strong>ugged, and <strong><u>S</u></strong>afe)is a <strong>sample preparation method</strong> that was initially developed in 2003 for <strong>analyzing veterinary drugs in food</strong>. The method was also tested for <strong>pesticide residue analysis in plant material</strong> with great success. In 2003, the <strong>detailed method was published</strong> in the journal AOAC International. Since then, the QuEChERS method has evolved into a <strong>sample preparation technique used on a variety of analytes</strong> in an <strong>expanding number of sample types</strong> before analysis by <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/gas-chromatography-mass-spectrometry-gc-ms.html"><strong>GC-MS</strong></a><strong> or </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms.html"><strong>LC-MS</strong></a>.</p><p><strong>Thermo Scientific QuEChERS kits</strong> contain <strong>pre-packaged, ready-weighed salts, sorbents, and buffers</strong> to <strong>streamline your workflow</strong> and <strong>minimize the potential for error</strong>. The kits are grouped according to your <strong>analytes of interest</strong>, <strong>sample matrix</strong>, and <strong>preferred QuEChERS method</strong>:</p><ul><li><strong>Original 2003 Method</strong></li><li><strong>AOAC 2007.01 Method</strong></li><li><strong>EN 15662 Method</strong></li><li><strong>NY/T 1380-2007 Method</strong></li></ul><p><strong>Complete packages</strong>—including both <strong>extraction and clean-up kits</strong>—are available. <strong>Extraction-only and cleanup-only kits</strong> are also offered to suit your laboratory’s sample preparation needs. These <strong>pre-packaged kits save time and money</strong>, make QuEChERS procedures <strong>easier and more convenient</strong>, and ensure <strong>quality to yield reproducible results</strong> and <strong>excellent recoveries</strong> for a wide variety of analytes.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_2_1e99f0c81b.jpg" alt="Thermo Scientific QuEChERS Sample Preparation Kits" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_2_1e99f0c81b.jpg 217w," sizes="100vw" width="891" height="640"></p><h3><strong>Typical QuEChERS workflow</strong></h3><div><div><div><div><div><p>As shown in the workflow diagram below, the <strong>QuEChERS method has four basic steps</strong>:</p><ol><li><strong>Homogenize sample</strong> (fruit or vegetable)</li><li><strong>Extract analytes of interest</strong> from a sample using <strong>extraction salts</strong> (pesticide residues, veterinary drugs, and/or mycotoxins)</li><li><strong>Clean-up the resulting supernatant</strong> using <strong>dispersive solid phase extraction (dSPE)</strong></li><li><strong>Analyze by GC-MS or LC-MS</strong></li></ol><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_496491ceff.jpeg" alt="Thermo Scientific QuEChERS Sample Preparation Kits" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_496491ceff.jpeg 245w," sizes="100vw" width="1170" height="706"></p><div><h3><strong>QuEChERS products</strong></h3></div><div><h4><strong>QuEChERS extraction kits for original 2003 method</strong></h4></div><div><p>The <strong>original QuEChERS method</strong> (Anastassiades et al, 2003) was developed by <strong>Steven J. Lehotay and Michelangelo Anastassiades</strong> in 2003 for the <strong>determination of pesticide residues in fruits and vegetables</strong>. The original method was created to <strong>analyze non-base-sensitive compounds</strong> and uses a <strong>sodium chloride buffer</strong> to <strong>reduce polar interferences</strong> and <strong>enhance extraction</strong>. <strong>Buffering</strong> is an important part of the QuEChERS procedure because it <strong>allows for analysis of pesticides and other residues</strong> that display <strong>pH dependence in their recoveries</strong>, depending on the <strong>sample matrix</strong>. <strong>Three different extraction kits</strong> are available to support the <strong>original 2003 QuEChERS method</strong>.</p><h5><strong>Chemicals used in the original 2003 method</strong></h5></div><ul><li><strong>Acetonitrile:</strong> Used to perform single-phase extraction (SPE) on a sample</li><li><strong>Anhydrous MgSO₄:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes remaining water from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>NaCl:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes residual water from sample; reduces polar interference and enhances extraction</li><li><strong>PSA:</strong> Primary secondary amine, used to remove polar matrix components, citric co-extractives, and free fatty acids, from sample during dispersive solid phase extraction (dSPE) step</li></ul><div><h4><strong>QuEChERS extraction and clean-up kits for AOAC 2007.01 method</strong></h4><p>The <strong>AOAC 2007.01 QuEChERS Method</strong> was developed by <strong>Steven J. Lehotay and his co-workers</strong>, who <strong>modified the original 2003 method</strong> to accommodate the use of <strong>acetate buffering at higher concentration</strong> for <strong>greater buffering strength</strong>. <strong>Buffering</strong> is an important part of the QuEChERS procedure because it <strong>allows for analysis of pesticides and other residues</strong> that display <strong>pH dependence in their recoveries</strong>, depending on the <strong>sample matrix</strong>. These <strong>extraction and clean-up products</strong> here support the <strong>AOAC 2007.01 method</strong>.</p><div><h5><strong>Chemicals used in the AOAC 2007.01 method</strong></h5><ul><li><strong>Acetonitrile:</strong> Used to perform single-phase extraction on a sample</li><li><strong>Anhydrous MgSO₄:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes remaining water from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>NaOAc:</strong> Buffers the sample to stabilize pH</li><li><strong>PSA:</strong> Primary secondary amine, used to remove polar matrix components, citric co-extractives, and free fatty acids, from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>C18:</strong> Removes fats, sterols, and other non-polar interferences from sample</li><li><strong>GCB:</strong> Graphitized carbon black, removes pigment (<i>not recommended for use with planar pesticides</i>)</li></ul><div><h4><strong>QuEChERS extraction and clean-up kits for EN 15662 method</strong></h4><p>The <strong>extraction and clean-up products</strong> here support the <strong>EN 15662 method</strong>. <strong>Widely used in Europe</strong>, the EN 15662 method was developed by <strong>Michelangelo Anastassiades and co-workers</strong>, who <strong>modified the original 2003 method</strong> to accommodate the use of <strong>citrate buffering at a relatively low buffering capacity</strong>. This variation uses a <strong>sodium chloride buffer</strong> to <strong>minimize polar interferences</strong> in addition to <strong>sodium citrate dihydrate</strong> and <strong>disodium citrate sesquihydrate buffers</strong>. <strong>Buffering</strong> is an important part of the QuEChERS procedure because it <strong>allows for analysis of pesticides and other residues</strong> that display <strong>pH dependence in their recoveries</strong>, depending on the <strong>sample matrix</strong>.</p><h5><strong>Chemicals used in the EN 15662 method</strong></h5><ul><li><strong>Acetonitrile:</strong> Used to perform single-phase extraction on a sample</li><li><strong>Anhydrous MgSO₄:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes remaining water from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>NaCl:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes residual water from sample</li><li><strong>Trisodium Citrate:</strong> Buffers the sample to stabilize pH</li><li><strong>Disodium Citrate Sesquihydrate:</strong> Buffers the sample to stabilize pH</li><li><strong>PSA:</strong> Primary secondary amine, used to remove polar matrix components, citric co-extractives, and free fatty acids, from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>C18:</strong> Removes fats, sterols, and other non-polar interferences from sample</li><li><strong>GCB:</strong> Graphitized carbon black, removes pigment (<i>not recommended for use with planar pesticides</i>)</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_3_721562526f.jpg" alt="Thermo Scientific QuEChERS Sample Preparation Kits" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_3_721562526f.jpg 245w," sizes="100vw" width="1471" height="488"></p><div><h4><strong>QuEChERS clean-up kit for NY/T 1380-2007 method</strong></h4></div><div><p>The <strong>NY/T 1380-2007 method</strong> is <strong>recommended by China Ministry of Agriculture</strong> for the <strong>QuEChERS Method sample preparation</strong> of <strong>51 specific pesticide residues</strong> in <strong>fruits and vegetables</strong> with <strong>analysis by GC-MS</strong>.</p><h5><strong>Chemicals used in the NY/T 1380-2007 method</strong></h5><ul><li><strong>Anhydrous MgSO₄:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes remaining water from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>PSA:</strong> Primary secondary amine, used to remove polar matrix components, citric co-extractives, and free fatty acids, from sample during dSPE step</li><li><strong>C18:</strong> Removes fats, sterols, and other non-polar interferences from sample</li></ul></div></div></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific Hypersil GOLD C18 Selectivity HPLC Columns

Achieve exceptional peak shape and resolution for your HPLC and LC/MS applications with Thermo Scientific™ Hypersil GOLD™ HPLC columns. 

<p><strong>Achieve exceptional peak shape and resolution for your HPLC and LC/MS applications with Thermo Scientific™ Hypersil GOLD™ HPLC columns.</strong> These endcapped, ultrapure, silica-based columns deliver significant reduction in peak tailing using generic gradients with C18 selectivity. With their excellent resolution, efficiency, and sensitivity, Hypersil GOLD columns give you confidence in the accuracy and quality of your analytical data.</p><h5><strong>Novel Bonding</strong></h5><ul><li>Proprietary derivatization and endcapping</li><li>C18 (USP L1) selectivity</li></ul><h5><strong>pH Stability</strong></h5><ul><li>Robust performance at high pH</li><li>Excellent column stability at low pH</li></ul><h5><strong>Flexible Formats</strong></h5><ul><li>Javelin HTS columns for high-throughput screening</li><li>Semi-preparative columns with 12 μm particles available</li></ul><h4><strong>About the Hypersil GOLD Family of HPLC Columns</strong></h4><p>Meet the challenges of modern chromatography with state-of-the-art columns that provide outstanding performance and consistent separations. Twelve different column chemistries are available so you can optimize separations and maximize productivity. Get outstanding peak shapes in reversed phase, ion exchange, HILIC, or normal phase chromatography.</p><ul><li>Excellent peak symmetry</li><li>Narrow peaks for outstanding efficiency</li><li>Enhanced sensitivity and improved resolution</li><li>Exceptional reproducibility for reliable chromatography, column after column</li><li>Solutions for high-throughput screening</li><li>1.9, 3, and 5 μm particle sizes for all your separation needs</li></ul><h4><strong>Specifications</strong></h4><ul><li><strong>Endcapped:</strong> Yes</li><li><strong>For Use With:</strong> LC/MS</li><li><strong>Max. Pressure: </strong>5800 psi (400 bar)</li><li><strong>Packing Material:</strong> Spherical, Fully Porous, Ultrapure Silica</li><li><strong>Stationary Phase:</strong> C18 Selectivity</li><li><strong>Surface Area:</strong> 220 m²/g</li><li><strong>Temperature:</strong> 60°C</li><li><strong>USP Type: </strong>L1</li><li><strong>Carbon Load</strong>: 11%</li><li><strong>Phase:</strong> Reversed Phase</li><li><strong>Pore Size: </strong>175 Å</li><li><strong>pH: </strong>1 to 11</li></ul>

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