The PE-22-28 Analysis is a targeted laboratory test designed to confirm the identity, determine the amount, and assess the peptide purity of PE-22-28 in lyophilised vials and raw active pharmaceutical ingredient (API) powders.
For lyophilised samples, results are reported in milligrams per vial together with peptide purity. Raw API powders can be evaluated using purity in % (m/m) together with peptide purity.
About PE-22-28
PE-22-28 is a synthetic heptapeptide derived from spadin, an endogenous peptide that inhibits the TREK-1 potassium channel. PE-22-28 was developed as a shorter spadin analogue with the amino acid sequence Gly-Val-Ser-Trp-Gly-Leu-Arg. It has been investigated primarily in preclinical studies focused on TREK-1 inhibition, neurogenesis, synaptogenesis, and antidepressant-like effects.
Key Features
- Targeted identification and quantification of PE-22-28
- Determination of peptide purity
- Suitable for lyophilised vials and raw API powders
- Analysis by HPLC
- Results for lyophilised samples reported in mg per vial and peptide purity
- Alternative result format for raw API powders includes purity in % (m/m) and peptide purity
- Minimum sample amount of one whole unopened vial with lyophilisate
- Minimum sample amount of 30 mg for raw API powders
- Average turnaround time of 7 business days
Analysis Parameters
- Target compound: PE-22-28
- Molecular weight: 789
- Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg-OH
- Testing method: HPLC
- Minimum amount of target compound for evaluation: Less than 1/20 of the usual dosage per vial
- Result format for lyophilised samples: mg per vial and peptide purity
- Result format for raw API powders: Purity in % (m/m) and peptide purity
- Minimum sample amount for lyophilised samples: One whole unopened vial with lyophilisate
- Minimum sample amount for raw API powders: 30 mg in a sealed glass vial to prevent the sample from absorbing moisture
- Average turnaround time: 7 business days
Important Notice
- This analysis is specifically intended for PE-22-28. It does not automatically screen the sample for spadin, other related peptides, degradation products, contaminants, or undeclared substances.
- For lyophilised samples, one whole unopened vial containing lyophilisate is required.
- Raw API powder should be supplied as at least 30 mg in a sealed glass vial to protect the sample from moisture.
- The alternative result format for raw API powders includes both purity in % (m/m) and peptide purity.
Optional Additional Analyses
The following optional laboratory services are available:
- TFA Analysis
- Complete Raw Analytical Data
- Fentanyl Screening
- Alternative Result Format: Purity in % (m/m)
- Batch Variance Testing
- pH Measurement
- Endotoxin Analysis
- CHNS Mass Report
- LCMS Screening for Peptide Contamination
- Sterility Testing (TAMC + TYMC)
- Heavy Metals Analysis (As, Cd, Pb, Hg)
- Additional Laboratory Report
