The Kisspeptin Analysis is a targeted laboratory test designed to confirm the identity, determine the amount, and assess the peptide purity of kisspeptin in lyophilised vials and raw active pharmaceutical ingredient (API) powders.
For lyophilised samples, results are reported in milligrams per vial together with peptide purity. Raw API powders can be evaluated using purity in % (m/m) together with peptide purity.
About Kisspeptin
Kisspeptins are naturally occurring neuropeptides derived from the KISS1 gene. The form covered by the supplied analysis parameters corresponds to kisspeptin-10 (KP-10), a 10-amino-acid peptide with the sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2.
Kisspeptin-10 activates the kisspeptin receptor KISS1R, also known as GPR54, and plays an important role in the neuroendocrine regulation of reproduction by stimulating gonadotropin-releasing hormone (GnRH) signalling.
Key Features
- Targeted identification and quantification of kisspeptin
- Determination of peptide purity
- Suitable for lyophilised vials and raw API powders
- Analysis by HPLC
- Results for lyophilised samples reported in mg per vial and peptide purity
- Alternative result format for raw API powders includes purity in % (m/m) and peptide purity
- Minimum sample amount of one whole unopened vial with lyophilisate
- Minimum sample amount of 30 mg for raw API powders
- Average turnaround time of 7 business days
Analysis Parameters
- Target compound: Kisspeptin
- CAS number: 374675-21-5
- Molecular weight: 1302 Da
- Sequence: H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
- Testing method: HPLC
- Minimum amount of target compound for evaluation: Less than 1/20 of the usual dosage per vial
- Result format for lyophilised samples: mg per vial and peptide purity
- Result format for raw API powders: Purity in % (m/m) and peptide purity
- Minimum sample amount for lyophilised samples: One whole unopened vial with lyophilisate
- Minimum sample amount for raw API powders: 30 mg in a sealed glass vial to prevent the sample from absorbing moisture
- Average turnaround time: 7 business days
Important Notice
- This analysis is specifically intended for kisspeptin. It does not automatically screen the sample for other kisspeptin forms, related peptides, degradation products, contaminants, or undeclared substances.
- The CAS number and sequence specified for this analysis correspond to kisspeptin-10 (KP-10).
- For lyophilised samples, one whole unopened vial containing lyophilisate is required.
- Raw API powder should be supplied as at least 30 mg in a sealed glass vial to minimise moisture absorption.
- The alternative result format for raw API powders includes both purity in % (m/m) and peptide purity.
Optional Additional Analyses
The following optional laboratory services are available:
- TFA Analysis
- Complete Raw Analytical Data
- Fentanyl Screening
- Alternative Result Format: Purity in % (m/m)
- Batch Variance Testing
- pH Measurement
- Endotoxin Analysis
- CHNS Mass Report
- LCMS Screening for Peptide Contamination
- Sterility Testing (TAMC + TYMC)
- Heavy Metals Analysis (As, Cd, Pb, Hg)
- Additional Laboratory Report
