XSelect HSS C18 is a general purpose, high performance C18 chemistry with exceptional retention and peak shape for all compounds. Packed in ultra-low dispersion hardware, 2.5 µm eXtended Performance [XP] columns enable exceptional separation performance, robustness and throughput for HPLC assays while enabling a seamless transition path toward UPLC adoption.
Waters: XSelect HSS C18 Column
Specifications
- Chemistry: C18
- Separation Mode: Reversed Phase
- Particle Substrate: Hybrid
- pH Range Min: 1 pH
- pH Range Max: 8 pH
- Maximum Pressure: 10000 psi (690 Bar)
- Endcapped: Yes
- Silanol Activity: Low
- Particle Shape: Spherical
- Pore Size: 100 Å
- System: UHPLC, UPLC
- Particle Technology: HSS
- USP Classification: L1
- Carbon Load: 15 %
The Waters XSelect HSS C18 HPLC Column is also available in these types:
XSelect HSS C18 SB XP Column
- The XSelect HSS C18 SB column is a low coverage, unendcapped C18 phase used for low pH separations that contain complex mixtures of basic and non-basic compounds. XSelect HSS C18 SB columns give you alternative analyte selectivity compared to most modern, high coverage, fully endcapped C18 stationary phases.
- Endcapped: No
- Bonding Technology: C18 SB
- Carbon Load: 8.5 %
XSelect Columns
Achieve unmatched reproducibility with a wide range of selectivity
Quickly and easily develop robust methods compatible with all modern chromatographic detection modes and transfer them from lab to lab with the XSelect Column family.
Designed to help you achieve reproducible and highly selective chromatographic separations, the XSelect Column family features two base particles technologies, Charged Surface Hybrid (CSH) and High Strength Silica (HSS). With XSelect Columns, method development scientists like you can achieve a wide range of selectivities across all application areas, without compromising performance.
Overview
- Designed for selectivity and stability at low pH
- Superior peak shape for basic compounds
- Highest analyte mass loading available
- Excellent batch-to-batch reproducibility
- Ideal for rapid method development
- CSH Column chemistries: C18, Fluoro-Phenyl (PFP), and Phenyl-Hexyl, available in 2.5 XP, 3.5, 5 μm analytical and 10 μm OBD preparative sizes
- HSS Column chemistries: HSS C18, C18 SB, and T3, available in 2.5 XP, 3.5, and 5 μm particle sizes
- Prolonged column lifetimes with optional VanGuard Cartridges specifically designed using XSelect stationary phases
- Recommended Use: For improving selectivity, peak shape, and retentivity in methods development.
Waters: XSelect Columns


