NATIVE MASS SPECTROMETRY DISTINGUISHES HOMO VS HETERO NON-COVALENT DIMERIC AGGREGATES OF MONOCLONAL ANTIBODIES

Agilent Biocolumns Aggregate/Fragment Analysis Application Compendium Contents Background 2 Getting Started 3 How to Guide - Size Exclusion Chromatography for Biomolecule Analysis - 5991-3651EN 4 Featured Application Notes Elevate Your mAb Aggregate Analysis - 5994-2709EN 1 22 22 High-Resolution, High-Throughput…

AN1611: High-Speed Process Monitoring with UHP-SEC-MALS Sophia Kenrick, Wyatt Technology Corp. Summary Introduction Size exclusion chromatography (SEC) is widely used for detecting aggregates, fragments, and other impurities in a biotherapeutic sample. When coupled with multi-angle light scattering (MALS), SEC enables…

The Analysis of Multimeric Monoclonal Antibody Aggregates by Size-Exclusion UPLC Stephan Koza, Matthew Lauber, and Kenneth J. Fountain Waters Corporation, Milford, MA, USA A P P L I C AT I O N B E N E F I T…

Rapid monitoring of mAb aggregates during the purification process development of therapeutic mAbs using a modified Orbitrap hybrid MS Reiko Kiyonami1, Ying Chen2, Nicole Zehethofer3, Catharina Crone3, AI De Leon2, Heiner Koch3, Min Du1 1Thermo Fisher Scientific, Lexington, MA; 2Thermo…