IMPROVING PEPTIDE CATABOLISM INTERPRETATION USING ION MOBILITY DATA AND SERVER-BASED DATA REVIEW WITH HELM INTEGRATION

[ APPLICATION NOTE ] Somatostatin Analogue Catabolite Screening and Identification Using Vion IMS QTof with WebMetabase Mark D. Wrona, 1 Jayne M. Kirk, 4 Ismael Zamora, 2 Tatiana Radchenko, 2 Anna Escola, 3 Antoni Riera, 3 Russell J. Mortishire-Smith4 Waters…

[ APPLICATION NOTE ] Metabolite Identification of Complex Cyclic Peptides Using WebMetabase, Ion Mobility-Enabled DIA, and Product Ion Confirmation Mark Wrona Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ Ability to screen metabolism from The incorporation of unnatural amino acids,…

ROUTINE METABOLITE IDENTIFICATION FOR COMPLEX PEPTIDES BASED ON IMS ENABLED QTOF DIA DATA ACQUISITION AND MASS-METASITE DATA PROCESSING Authors: Yun W. Alelyunas, Nathan Anderson, Mark D. Wrona Affiliations: Waters Corporation, Milford, MA, USA INTRODUCTION In therapeutic peptide drug discovery and…

[ APPLICATION NOTE ] Ion Mobility-Enabled Metabolite Identification of Tienilic Acid and Tienilic Acid Isomer Using Mass-MetaSite and WebMetabase Lauren Mullin, 1 Giorgis Isaac, 1 Ian Wilson, 2 Adam King, 3 Nathan Anderson, 1 Russell Mortishire-Smith, 3 Robert Plumb 1…