IMPROVING PEPTIDE CATABOLISM INTERPRETATION USING ION MOBILITY DATA AND SERVER-BASED DATA REVIEW WITH HELM INTEGRATION Authors: Mark Wrona1, Gordon Murray2, Yun Alelyunas1, Russell Mortishire-Smith3, Antoni Riera5, Tatiana Radchenko4, Anna Escola5, Ismael Zamora4, Jayne Kirk3 Affiliations: 1Waters Corporation, Milford, MA, USA,…
[ APPLICATION NOTE ] Metabolite Identification of Complex Cyclic Peptides Using WebMetabase, Ion Mobility-Enabled DIA, and Product Ion Confirmation Mark Wrona Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ Ability to screen metabolism from The incorporation of unnatural amino acids,…
ROUTINE METABOLITE IDENTIFICATION FOR COMPLEX PEPTIDES BASED ON IMS ENABLED QTOF DIA DATA ACQUISITION AND MASS-METASITE DATA PROCESSING Authors: Yun W. Alelyunas, Nathan Anderson, Mark D. Wrona Affiliations: Waters Corporation, Milford, MA, USA INTRODUCTION In therapeutic peptide drug discovery and…
[ APPLICATION NOTE ] Ion Mobility-Enabled Metabolite Identification of Tienilic Acid and Tienilic Acid Isomer Using Mass-MetaSite and WebMetabase Lauren Mullin, 1 Giorgis Isaac, 1 Ian Wilson, 2 Adam King, 3 Nathan Anderson, 1 Russell Mortishire-Smith, 3 Robert Plumb 1…
