Enhancing The Quality Of Peptide Mapping Separation For The Analysis Of PTM

Application Note Biotherapeutics and Biosimilars In-depth Peptide Mapping with Iterative MS/MS Acquisition on the Agilent 6545XT AdvanceBio LC/Q‑TOF Authors Introduction Linfeng Wu and David L. Wong Agilent Technologies, Inc. Santa Clara, CA, USA Therapeutic monoclonal antibodies (mAbs) represent one of…

Fast and Efficient Peptide Mapping of a Monoclonal Antibody (mAb): UHPLC Performance with Superficially Porous Particles Application Note Biotherapeutics and Biosimilars Authors Introduction James Martosella, Alex Zhu Peptide mapping by reversed-phase (RP) chromatography is the mainstay technique in biotherapeutic analysis,…

Application Note Peptide Mapping of Trastuzumab Tryptic Digests on an Agilent 6545XT AdvanceBio LC/Q-TOF Author Stephen Sciuto, PhD Agilent Technologies, Inc. Abstract This application note describes a peptide mapping strategy to analyze tryptic digests of trastuzumab on an Agilent 6545XT…

Application Note Biotherapeutics and Biosimilars LC/MS/MS Peptide Mapping Comparison of Innovator and Biosimilars of Rituximab Author Suresh Babu C.V. Agilent Technologies, Inc. Abstract The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products. This Application Note presents…