High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Cytochrome P450 Inhibition

High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Cytochrome P450 Inhibition Application Note Authors Vaughn Miller Agilent Technologies, Inc. Wakefield, MA, USA Introduction Analysis of cytochrome P450 (CYP) inhibition is an important component of the drug discovery process as…

High-Throughput Analysis of Cytochrome P450 Inhibition in Intact Human Hepatocytes Application Note Authors Abstract Kari E. Schlicht and Vaughn P. Miller Ultrafast methods of analysis were developed using the Agilent RapidFire Agilent Technologies, Inc. High‑Throughput Mass Spectrometry System in combination…

Development of Label-Free, Enzymatic CYP17A1 Assays Using the Agilent 6150 Single Quadrupole LC/MS System Application Note Authors Abstract Robert Wurm and Kenneth Lewis OpAns, LLC Durham, NC USA This application note describes the development of fast, label-free in vitro enzymatic…

Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening of β-Amyloid Secretase (BACE-1) Using Fluorescence Spectroscopy and Ultrafast SPE/MS/MS Application Note Authors Introduction Lauren E. Frick and William A. LaMarr Agilent Technologies, Inc. Wakefield, MA, USA Fragment-based screening offers advantages over…