High-Throughput Fluorescence-Based mAbs Aggregation Analysis Workflow

APPLICATION NOTE Conquer ADC stability characterization with Aunty Introduction Conjugating potent cytotoxic payloads to monoclonal antibodies results in powerful anti-cancer therapeutics, but the resulting antibody-drug conjugates (ADCs) have unique stability challenges.1 Attaching a hydrophobic small molecule drug to a hydrophilic…

APPLICATION NOTE Meet Aunty – the Queen of protein stability Introduction Aunty is the fastest, highest throughput protein stability platform on the planet (Figure 1). Other stability methods each have their drawbacks: some are slow, others don’t give the full…

APPLICATION NOTE Uncle stays hot for proteins with isothermal apps Introduction Testing the isothermal stability of proteins at high-throughput as early as candidate screening is the fastest way to see which ones would fail long-term storage trials. Unfolding and aggregation…

Agilent Biocolumns Aggregate/Fragment Analysis Application Compendium Contents Background 2 Getting Started 3 How to Guide - Size Exclusion Chromatography for Biomolecule Analysis - 5991-3651EN 4 Featured Application Notes Elevate Your mAb Aggregate Analysis - 5994-2709EN 1 22 22 High-Resolution, High-Throughput…