Climbing the oligonucleotide ladder toward rapid and wide-ranging oligonucleotide analysis using MALDI-MS

May 2023 Newsletter NEW SEPARATION APPROACH Oligonucleotides Analysis by HPLC Many organic molecules of medical, pharmaceutical, industrial, and environmental interest can exist in an ionic form at specific pH levels. One such example is Oligonucleotides (OGNs), which are important group…

Automated High-Throughput Oligo QC: From Automated Sample Preparation to MALDI Spectra Assessment Synthetic oligonucleotides find a variety of applications in molecular biology. Primers for instance are used for DNA sequencing and amplification. Mass spectrometry is a well-established technology for quality…

The Analysis of Human Haemoglobin Variants using Mass Spectrometry Brian N. Green Edited by Michael R. Morris & Jonathan P. Williams The Analysis of Human Haemoglobin Variants using Mass Spectrometry Brian N. Green Edited by Michael R. Morris & Jonathan…

Application Note Biopharma/Pharma An Integrated Workflow for the Analysis of Oligonucleotides and Their Impurities by Agilent High-Resolution LC/(Q-)TOF Mass Spectrometry Separation, characterization, and relative quantitation of target oligonucleotides and their impurities Authors David L. Wong and Peter Rye Agilent Technologies,…