Optimized digestion procedure and characterization for monoclonal antibodies and proteins by CESI-MS

Comprehensive analysis of low abundant mannose glycopeptides in peptide mapping of adalimumab Featuring CESI 8000 Plus and TripleTOF ® 6600+ System Zuzana Demianova1, Miloslav Sanda2, Zoe Zhang3, Sean McCarthy4 and Sahana Mollah3 1 SCIEX, Brea, CA; 2 Georgetown University, Washington,…

Charge Heterogeneity Analysis of Intact Infliximab Using CESI-MS and Neutral OptiMS Cartridge Fang Wang1, Tingting Li1, Esme Candish2 1 SCIEX, Brea, CA; 2SCIEX, Framingham, MA; Key Features • Capillary zone electrophoresis (CZE) separation and Mass spectrometric (MS) identification of charge…

CESI 8000 Plus High Performance Separation-ESI Module • Increased coverage from limited samples • High-resolution separation of polar analytes and critical PTMs • In-depth characterization of proteoforms and protein complexes Expand the reach of your mass spectrometer The CESI 8000…

Simple Solutions to Complex Workflows Innovation for Biotherapeutic Peptide Mapping Peptide Mapping for Every Mass Spec User Comprehensive peptide mapping of biologics is not a simple task. Usually, a mass spec expert needs to develop protocols and analyze the data…