Charge Heterogeneity Analysis of Intact Infliximab Using CESI-MS and Neutral OptiMS Cartridge

Subunit charge variant characterization in the native state Fang Wang1 Zoe Zhang2, 1SCIEX Brea, CA (USA) 2 SCIEX Redwood City, CA (USA), Monoclonal antibody (mAb) therapeutics often contain charge variants that arise from a wide array of post-translational modifications (PTM),…

Application Note Pharma & Biopharma Monoclonal Antibody Charge Variants Identification by Fully Automated Capillary Isoelectric Focusing – Mass Spectrometry Authors Tony Wang, James Xia, and Rena Wang CMP Scientific Corp, Brooklyn, NY, USA Jens Meixner Agilent Technologies, Inc. Waldbronn, Germany…

Native State Charge Variant Analysis of Commercialized Monoclonal Antibodies in Minutes CZE Rapid Charge Variant Analysis Kit Peter Holper, SCIEX Redwood City, CA Introduction A As biopharmaceutical companies face increasing pressure to decrease the overall drug development timeline, analytical researchers…

[ APPLICATION NOTE ] Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAb Column, IonHance CX-MS pH Concentrates, and BioAccord System Samantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION…