Mass Spectrometric Characterization of Antibody-siRNA Conjugates using the Agilent 6545XT AdvanceBio LC/Q‑TOF

Agilent BioHPLC columns Characterization of Antibody-Drug Conjugate Critical Quality Attributes Application compendium Contents Introduction3 Featured application notes 2 PLRP-S Polymeric Reversed-Phase Column for LC/MS Separation of mAbs and ADC (5991-7163EN) 5 Intact- and Peptide-Level Characterization of Trastuzumab Emtansine In Vitro…

Poster Reprint ASMS 2020 WP 004 Mass Spectrometric Characterization of Antibody-RNA Conjugates using the Agilent 6545XT AdvanceBio LC/Q-TOF David L. Wong Agilent Technologies, Inc., Santa Clara, CA, USA Introduction Experimental Antibody-RNA Conjugates have drug-like The antibody was partially reduced with…

Application Note Biopharma/Pharma Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS Authors David L. Wong and Sarah M. Stow Agilent Technologies, Inc. Abstract Antibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb) conjugated to a small molecule drug…

Application Note Pharma & Biopharma Sensitive Native Mass Spectrometry of Macromolecules Using Standard Flow LC/MS Author David L. Wong Agilent Technologies, Inc. Abstract Native mass spectrometry can be used for a variety of protein-based applications, such as protein-protein interaction, protein-ligand…