Sensitive Native Mass Spectrometry of Macromolecules Using Standard Flow LC/MS

Agilent Biocolumns Aggregate/Fragment Analysis Application Compendium Contents Background 2 Getting Started 3 How to Guide - Size Exclusion Chromatography for Biomolecule Analysis - 5991-3651EN 4 Featured Application Notes Elevate Your mAb Aggregate Analysis - 5994-2709EN 1 22 22 High-Resolution, High-Throughput…

Application Note Biopharma Comprehensive Approaches to Higher-Order Structure of Intact Proteins by Native Mass Spectrometry Authors Caroline S. Chu, Patrick D. Perkins, Christian Klein, and Andrew Gieschen Agilent Technologies, Inc. Abstract This application note presents different approaches to native mass…

Application Note Biopharma/Pharma Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS Authors David L. Wong and Sarah M. Stow Agilent Technologies, Inc. Abstract Antibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb) conjugated to a small molecule drug…

Application Note Pharma & Biopharma Mass Spectrometric Characterization of Antibody-siRNA Conjugates using the Agilent 6545XT AdvanceBio LC/Q‑TOF Author David L. Wong Agilent Technologies, Inc. Abstract Small interfering RNAs (siRNAs) are a promising type of RNA-based therapeutic drugs that demonstrate effectiveness…