Method Development for Forced Degradation of Small Molecule GLP-1 Agonist Orforglipron

Application Note Method Development for the Forced Degradation of Next-generation Selective Estrogen Receptor Degrader Imlunestrant Melissa Aiello, Christopher Collins, Thomas H. Walter Waters Corporation, United States Published on June 05, 2026 Abstract With whole libraries of new therapy targets in…

Application Note Method Development of Orlistat Forced Degradation Sample using MaxPeak™ Premier Columns and QDa™ Mass Detection Kenneth D. Berthelette, Christopher Collins, Jamie Kalwood, Kim Haynes Waters Corporation Abstract New drug development requires a variety of testing to ensure safety…

Application Note Method Development of Proteolysis Targeting Chimera (PROTAC) Compound ARV-825 Forced Degradation Sample Using the Systematic Screening Protocol Kenneth D. Berthelette, Christopher Collins, Kim Haynes Waters Corporation Abstract Forced degradation studies are one way to determine how a chemical…

Application Note Analytical Quality by Design Method Development and Optimization of an Impurity Profiling Method for GLP-1 Receptor Agonist Exenatide Pawel Bigos, Robert E. Birdsall, Duanduan Han, Karen Nyholm Waters Corporation, United-States Published on March 06, 2025 Abstract An analytical…