Method Development of Proteolysis Targeting Chimera (PROTAC) Compound ARV-825 Forced Degradation Sample Using the Systematic Screening Protocol

Application Note Degradation Products of ARV-825 Proteolysis Targeting Chimera (PROTAC) Compound: Isolation and Purification Using Analytical Scale Fraction Collection Margaret Maziarz, Paul Rainville, Stephanie N Harden Waters Corporation, United States Published on July 10, 2025 Abstract Proteolysis targeting chimeras (PROTACs)…

IMPURITIES INVESTIGATION OF ARV-825 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOUND THROUGH FRACTION COLLECTION Authors: Margaret Maziarz, Paul Rainville Affiliations: Waters Corporation, 34 Maple Street, Milford MA 01757 Mass-directed fraction collection Forced degradation sample The ARV-825 sample was dissolved in a 45:55…

IMPURITIES INVESTIGATION OF ARV-825 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOUND THROUGH FRACTION COLLECTION Authors: Margaret Maziarz, Paul Rainville Affiliations: Waters Corporation, 34 Maple Street, Milford MA 01757 Mass-directed fraction collection Forced degradation sample The ARV-825 sample was dissolved in a 45:55…

Application Note Method Development of Orlistat Forced Degradation Sample using MaxPeak™ Premier Columns and QDa™ Mass Detection Kenneth D. Berthelette, Christopher Collins, Jamie Kalwood, Kim Haynes Waters Corporation Abstract New drug development requires a variety of testing to ensure safety…