Degradation Products of ARV-825 Proteolysis Targeting Chimera (PROTAC) Compound: Isolation and Purification Using Analytical Scale Fraction Collection

IMPURITIES INVESTIGATION OF ARV-825 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOUND THROUGH FRACTION COLLECTION Authors: Margaret Maziarz, Paul Rainville Affiliations: Waters Corporation, 34 Maple Street, Milford MA 01757 Mass-directed fraction collection Forced degradation sample The ARV-825 sample was dissolved in a 45:55…

IMPURITIES INVESTIGATION OF ARV-825 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOUND THROUGH FRACTION COLLECTION Authors: Margaret Maziarz, Paul Rainville Affiliations: Waters Corporation, 34 Maple Street, Milford MA 01757 Mass-directed fraction collection Forced degradation sample The ARV-825 sample was dissolved in a 45:55…

Application Note Method Development of Proteolysis Targeting Chimera (PROTAC) Compound ARV-825 Forced Degradation Sample Using the Systematic Screening Protocol Kenneth D. Berthelette, Christopher Collins, Kim Haynes Waters Corporation Abstract Forced degradation studies are one way to determine how a chemical…

Application Note Analytical Scale Isolation and Purification of Propranolol Impurities Including Nitrosamine Drug Substance Related Impurity (NDSRI) Margaret Maziarz, Paul Rainville, Stephanie Harden Waters Corporation, United States Published on Novemebr 07, 2025 Abstract Nitrosamine drug substance-related impurities (NDSRIs) are a…