Improving LC-MS Analysis of mRNA: Enzymatic Digestion and LC-MS Analysis for Characterization of mRNA Modifications and Sequence Integrity

Application Note Oligo Mapping of mRNA Digests Using a Novel Informatics Workflow Catalin E. Doneanu, Chris Preston, Matt Gorton, Tatiana Johnson, Bala Addepalli, Ying Qing Yu Waters Corporation Abstract Recent advances in LC-MS and informatics technologies are supporting scientists in…

Application Note Sequence Mapping of mRNA Digests Using the Xevo™ MRT Mass Spectrometer and waters_connect™ MAP Sequence 2.0 Application Catalin Doneanu, Alexandre F. Gomes, Chris Preston, Matt Gorton, Tatiana Johnston, Bala Addepalli, Ying Qing Yu Waters Corporation, United States Published…

RNA SEQUENCE MAPPING VIA ENDONUCLEASE DIGESTION AND LC-MS ANALYSIS VIA NOVEL INFORMATICS WORKFLOWS Catalin Doneanu1, Chris Preston2, Matt Gorton2, Alexandre F. Gomes1, Tatiana Johnston1, Bala Addepalli1, Nick Pittman2 and Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation,…

Application Note RNA Digestion Product Mapping Using an Integrated UPLC-MS and Informatics Workflow Catalin E. Doneanu, Chris Preston, Matt Gorton, Tatiana Johnson, Bala Addepalli, Ying Qing Yu Waters Corporation Abstract LC-MS analysis is an indispensable tool for single-guide RNA (sgRNA)…