Enhanced HCP quantitation LC-MS/MS workflow solution using a MS sample prep method

An improved EasyPep sample preparation method for enrichment and quantitation of host cell proteins Jae Choi1, Philip Remes2 ,Oleg Silivra2, Cristina C. Jacob2, Terry Hicks3, Matthew Daniels3, Nikki Jarrett1, Kay Opperman1, Bhavin Patel1 1Thermo Fisher Scientific, Rockford, IL, 2Thermo Fisher…

High-sensitivity Host Cell Protein (HCP) analysis on a new Orbitrap Excedion Pro BioPharma hybrid mass spectrometer with optimized sample preparation Xiaoxi Zhang1, Reiko Kiyonami2, Jae Choi3, Bhavin Patel3, Cong Wang4, Peter Krueger4, Heiner Koch4, Min Du2. 1 Thermo Fisher Scientific,…

Increasing sensitivity of high throughput host cell protein analysis on a novel highresolution accurate mass platform Eugen Damoc1; Tabiwang N. Arrey1; Anna Pashkova1; Eduard Denisov1; Kai Scheffler2; Kristina Srzentić3 1Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany; 2Thermo Fisher Scientific, Germering,…

APPLICATION NOTE 73412 Residual host cell protein analysis of NISTmAb: From simplified sample preparation to reliable results Authors: Amy Claydon, Phil Widdowson, and Andrew Williamson Thermo Fisher Scientific, Hemel Hempstead, UK Keywords: Host cell protein assay, HCP, monoclonal antibody, mAb,…