Balancing sensitivity and throughput in single-cell proteomics using low-nanoflow LC-MS

A high-sensitivity high-throughput LCMS platform for single-cell proteomics and low sample amount analysis Runsheng Zheng1, Christopher Pynn1, Manuel Matzinger2, Karl Mechtler2, Alexander Makarov3, Wim Decrop1, Alec Valenta1, Martin Samonig1 1Thermo Fisher Scientific, Germering, Germany; 2Institute of Molecular Pathology, Vienna, Austria;…

High-throughput LC-MS Enhancing sample throughput for deep dive proteomics with Tandem LC Runsheng Zheng1, Martin Rendl1, Alec Valenta2, Tabiwang Arrey3, Christopher Pynn1, Yuan Lin4, Maksim Daniliuk5, Ece Aydin1 Robert van Ling6, Wim Decrop1, Felix Josef7, Til Reinhardt3, Nagarjuna Nagaraj7, Andreas…

Technical note | 001939 Proteomics High-sensitivity low-nano flow LC-MS methods for high-throughput sample-limited proteomics Authors Goal Runsheng Zheng, Alec Valenta, Demonstrate high-throughput and high-sensitivity nano-flow LC-MS methods using a Christopher Pynn, Ece Aydin, 50 μm i.d. column operated at 100…

Technical note | 003335 Omics Maximizing sample throughput and sensitivity in nano- and capillary-LC-MS Harnessing a tandem direct injection workflow and a dual spray ion source Authors Goal Runsheng Zheng , Martin Rendl , Alec C. Valenta2, Christopher Pynn1, Till…